基于成分及药效差异的江苏省莪术临床应用调查分析
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篇名: 基于成分及药效差异的江苏省莪术临床应用调查分析
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摘要: 目的:为临床合理使用莪术提供参考。方法:通过文献检索,对不同来源和不同炮制品莪术的化学成分及药效差异进行总结;通过文献检索、电话咨询、网络检索等方式,对不同来源、不同炮制品的莪术生产情况及在江苏省制剂、临床中的应用情况进行分析。结果:挥发油含量以温郁金为最高,蓬莪术中姜黄素含量最高,广西莪术中莪术二酮、莪术醇、吉马酮及姜黄素等4种主要活性成分含量较低,且不同产地的广西莪术中成分差异较大。对2016年四川、广西壮族自治区、浙江的莪术药材年产量调查结果显示,广西莪术的年产量为最高,温郁金与蓬莪术的年产量相对较低。在调查的全国14家莪术油生产企业中,12家企业以温郁金为提取原料,2家企业以蓬莪术为提取原料。江西省的9家莪术油生产企业多以本地生产的温郁金为提取原料,但原料并不是来自于温郁金的道地产区——浙江省。在调查的江苏省10家三级甲等中医院及20家零售中药店中,使用的品种主要为蓬莪术和广西莪术,其中广西莪术的使用比例约为70%,温郁金在临床上使用得很少。在临床上使用的主要炮制品种是醋莪术,极少为生品莪术。结论:目前在莪术的临床应用中存在着炮制品的选择面窄、药品质量参差不齐的问题,可通过在药材产地培育优良品种、加大蓬莪术的药材种植量、药品的监管部门对医院及零售药店中提供的莪术炮制品种进行严格规定等来解决。
ABSTRACT: OBJECTIVE: To provide reference for clinical rational use of curcumae rhizoma. METHODS: According to literature retrieval, the chemical structures, ingredient and efficacy difference of curcumae rhizoma with different sources and difference processed products were summed up. According to literature retrieval, telephone consultation and network retrieval, the production status of products with different sources and difference processing and the application in clinic and preparations in Jiangsu province were analyzed. RESULTS: The volatile oil content was the highest in Curcuma wenyujin; curcumin content was the highest in Curcuma phaeocaulis; the contents of 4 main active ingredients (curdione, curcumol, germacrone and curcumin) were relatively lower in Curcuma kwangsiensis, and there were quite different ingredients in the C. kwangsiensis from different producing areas. Results of investigating the annual output of medicinal materials in Sichuan, Guangxi and Zhejiang in 2016 showed, the annual output of C. kwangsiensis was the highest, and C. wenyujin and C. phaeocaulis were relatively lower. In the investigated 14 manufacturers producing curcumae rhizoma oil in China, 12 took C. wenyujin and 2 took C. phaeocaulis as raw material. While the 9 manufacturers in Jiangxi province mostly took C. wenyujin (locally produced) as raw material, which was not from the genuine producing area-Zhejiang province. In the 10 third-grade class-A TCM hospitals and 20 retail TCM pharmacies in Jiangsu province, the C. phaeocaulis and C. kwangsiensis were mainly used, in which, the use proportion of C. kwangsiensis accounted for about 70%, and C. wenyujin used little in clinic. The main processed product in clinic was curcumae rhizoma processed by vinegar, and crude product was rarely used. CONCLUSIONS: Currently, the clinical use of curcumae rhizoma shows problems in narrow selection of processed products and uneven quality, which can be solved by cultivating fine varieties in producing areas, increasing the planting amount of C. phaeocaulis, drug regulatory authorities’ strict rules for processed products of curcumae rhizoma in hospitals and retail pharmacies.
期刊: 2017年第28卷第28期
作者: 顾黎云,杜沙莉,张磊,宋珅
AUTHORS: GU Liyun,DU Shali,ZHANG Lei,SONG Shen
关键字: 莪术;成分;药效;临床应用;调查分析;江苏
KEYWORDS: Curcumae rhizoma; Ingredients; Efficacy; Clinical use; Investigation and analysis; Jiangsu
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