西酞普兰联合石杉碱甲对老年抑郁模型大鼠的改善作用
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篇名: 西酞普兰联合石杉碱甲对老年抑郁模型大鼠的改善作用
TITLE:
摘要: 目的:研究西酞普兰联合石杉碱甲对老年抑郁大鼠的改善作用。方法:将老年大鼠随机分为空白对照组、模型组、石杉碱甲组(0.3 mg/kg)、西酞普兰组(5 mg/kg)及联用组(石杉碱甲0.3 mg/kg+西酞普兰5 mg/kg),每组10只。除空白对照组外,其余各组大鼠采用慢性不可预知温和应激方式建立抑郁模型,成模后每天ig给予相应药物1次,连续给药2周。通过旷场实验、糖水消耗实验、悬尾实验、强迫游泳实验、Morris水迷宫实验观察各组大鼠的抑郁和学习记忆行为变化。结果:与空白对照组比较,模型组大鼠水平穿格次数和直立次数、糖水偏好率、站台穿越次数、目标象限路程百分比、目标象限时间百分比均明显减少或降低(P<0.05或P<0.01),悬尾不动时间、游泳不动时间和逃避潜伏期均明显延长(P<0.05或P<0.01)。与模型组比较,西酞普兰组和联用组大鼠抑郁相关指标均明显改善(P<0.05或P<0.01),其中联用组效果更好;联用组大鼠学习记忆相关指标均明显改善(P<0.05或P<0.01),石杉碱甲组和西酞普兰组大鼠仅站台穿越次数明显增加(P<0.05或P<0.01),其他学习记忆相关指标无明显变化(P>0.05)。结论:西酞普兰联合石杉碱甲能明显改善老年抑郁模型大鼠的抑郁行为和学习记忆能力,效果优于单用西酞普兰。
ABSTRACT: OBJECTIVE: To study the improvement effects of citalopram combined with huperzine A in aged depression model rats. METHODS: Aged rats were randomly divided into blank control group, model group, huperzine A group (0.3 mg/kg), citalopram group (5 mg/kg), and combination group (huperzine A 0.3 mg/kg+citalopram 5 mg/kg), 10 in each group. Except for blank control group, rats in other groups received chronic unpredictable mild stress to reduce depression model. After modeling, rats were intragastrically administrated relevant drugs once a day, for 2 weeks. The depression, learning and memory behavior changes of rats in each group were observed by using open-field test, sucrose consumption test, tail suspension test, forced swimming test and Morris water maze test. RESULTS: Compared with blank control group, the horizontal crossing number, uprightness number, sucrose preference rate, crossing number in platform, percentages of target quadrant distance and time of rats in model group were obviously decreased (P<0.05 or P<0.01); immobility time of tail suspension and swimming, escape latency were obviously prolonged (P<0.05 or P<0.01). Compared with model group, the depression-related indexes of rats in citalopram group and combination group were obviously improved (P<0.05 or P<0.01), and combination group had better effects; the learning and memory-related indexes in combination group were obviously improved (P<0.05 or P<0.01), only crossing time in platform in huperzine A group and citalopram group were obviously increased (P<0.05 or P<0.01), and other learning and memory-related indexes had no obvious changes (P>0.05). CONCLUSIONS: Citalopram combined with huperzine A can obviously improve the depression behavior, learning and memory ability of aged rats with depression, showing better effects than citalopram alone.
期刊: 2017年第28卷第28期
作者: 谭攀攀,刘蒙,李秀英,张朋艳,杜雨辰
AUTHORS: TAN Panpan,LIU Meng,LI Xiuying,ZHANG Pengyan,DU Yuchen
关键字: 西酞普兰;石杉碱甲;联合治疗;老年大鼠;抑郁;学习记忆
KEYWORDS: Citalopram; Huperzine A; Combined treatment; Aged rats; Depression; Learning and memory
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