海昆肾喜胶囊治疗慢性肾功能衰竭的Meta分析
x

请在关注微信后,向客服人员索取文件

篇名: 海昆肾喜胶囊治疗慢性肾功能衰竭的Meta分析
TITLE:
摘要: 目的:系统评价海昆肾喜胶囊治疗慢性肾功能衰竭 (CRF) 的疗效,为临床提供循证参考。方法:计算机检索Central、PubMed、EMBase、中国期刊全文数据库(CJFD)、中国生物医学文献数据库(CBM)、中文科技期刊数据库(VIP)和万方数据库,收集海昆肾喜胶囊联合常规方案(试验组)对比单纯常规方案(对照组)治疗CRF的随机对照试验(RCT),筛选文献、提取资料并采用Cochrane协作网提供的风险偏倚评估图评价质量后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入10项RCT,合计704例患者。Meta分析结果显示,试验组患者总有效率显著高于对照组[RR=4.42,95%CI(2.70,7.22),P<0.001],血肌酐[MD=-140.37,95%CI(-191.72,-89.03),P<0.001]、血尿素氮[MD=-5.49,95% CI(-8.36,-2.63),P<0.001]和24 h尿蛋白定量[MD=-0.43,95%CI(-0.62,-0.23),P<0.001]均显著低于对照组,差异均有统计学意义。结论:海昆肾喜胶囊治疗CRF疗效较好,可以显著改善患者相关肾功能指标。
ABSTRACT: OBJECTIVE: To systematically review therapeutic efficacy of Haikun shenxi capsule in the treatment of chronic renal failure (CRF). METHODS: Retrieved from Central, PubMed, EMBase, CJFD, CBM, VIP and Wanfang database, randomized clinical trials (RCTs) about Haikun shenxi capsule combined with routine treatment (trial group)vs. single routine treatment (control group) in the treatment of CRF were collected. Meta-analysis was performed by Rev Man 5.3 software after screening literature, extracting data and evaluating quality by using risk bias evaluation of Cochrane collaboration network. RESULTS: A total of 10 RCTs were included eventually, involving 704 patients. The results of analysis showed that compared to general therapy, Haikun shenxi capsule could improve total effective rate [RR=4.42,95%CI(2.70,7.22),P<0.001], and could reduce SCr[MD=-140.37,95%CI(-191.72,-89.03),P<0.001], BUN[MD=-5.49,95%CI(-8.36,-2.63),P<0.001] and 24 h-Upro[MD=-0.43,95%CI(-0.62,-0.23),P<0.001],with statistical significance. CONCLUSIONS: The clinical efficacy of Haikun shenxi capsule in the treatment of CRF is good and significantly improve related indexes of renal function.
期刊: 2017年第28卷第27期
作者: 刘枚芳,黄家晟,何嘉炜,华俏丽,张蕾,刘旭生
AUTHORS: LIU Meifang,HUANG Jiasheng,HE Jiawei,HUA Qiaoli,ZHANG Lei,LIU Xusheng
关键字: 海昆肾喜胶囊;慢性肾功能衰竭;Meta分析;系统评价;疗效
KEYWORDS: Haikun shenxi capsule; Chronic renal failure; Meta-analysis; System review; Therapeutic efficacy
阅读数: 601 次
本月下载数: 15 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!