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临床药师干预我院呼吸内科抗菌药物使用的效果评价
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| 篇名： | 临床药师干预我院呼吸内科抗菌药物使用的效果评价 |
| TITLE： | |
| 摘要： | 目的：评价临床药师对我院呼吸内科感染患者抗菌药物使用的干预效果。方法：选取我院呼吸内科2016年1－6月和2016年7－12月感染住院患者各500例，分别为干预前组和干预后组，比较临床药师干预前后两组患者抗菌药物使用情况、不良反应发生情况以及抗感染效果，评价抗菌药物使用的合理性。结果：干预后，抗菌药物使用率由干预前的92.60％下降至74.20％，其中采用单药、三联及以上治疗的患者比例均显著下降，差异均有统计学意义（P＜0.05）；不良反应发生率由干预前的14.20％下降至5.80％，感染控制率由干预前的95.03％上升至97.04％，且抗菌药物费用显著降低，差异均有统计学意义（P＜0.05）；用药不合理、用量不规范、联合用药不合理、无病原学支持的发生率及总不合理率分别由干预前的7.40％、3.60％、5.80％、7.80％、20.60％下降至4.00％、1.40％、2.00％、4.20％、9.60％，差异均有统计学意义（P＜0.05）。而干预前后采用二联治疗的患者比例、急重症抢救率比较，差异均无统计学意义（P＞0.05）。结论：临床药师实施的干预有效降低了抗菌药物使用率和不良反应发生率，提高了感染控制率，减少了抗菌药物的费用和不合理用药现象的发生；但我院呼吸内科仍存在用药不合理、用量不规范、联合用药不合理、无病原学支持等现象，尚需后续持续干预。 |
| ABSTRACT： | OBJECTIVE： To evaluate the effect of clinical pharmacist intervention on the application of antibiotics in patients with respiratory infection from our hospital. METHODS： Each 500 patients were selected from respiratory department of our hospital during Jan. to Jun. in 2016 and Jul. to Dec. in 2016. The patients were divided into pre-intervention group and post-intervention group. The application of antibiotics， the occurrence of ADR and anti-infective effects were compared before and after clinical pharmacist intervention， and the rationality of antibiotics use was evaluated. RESULTS： After intervention， the utilization rate of antibiotics decreased from 92.60％ to 74.20％； the proportion of single drug therapy and triple and more drugs therapy were decreased significantly， with statistical significance （P＜0.05）. The incidence of ADR reduced from 14.20％ to 5.80％； the rate of infection control increased from 95.03％ before intervention to 97.04％； antibiotics cost decreased significantly， with statistical significance （P＜0.05）. The incidence of irrational drug use， nonstandard dosage， irrational drug combination and no etiological support as well as total irrational rate decreased from 7.40％， 3.60％， 5.80％， 7.80％， 20.60％ to 4.00％， 1.40％， 2.00％， 4.20％， 9.60％， with statistical significance （P＜0.05）. There was no statistical significance in the proportion of double drug therapy or emergency and severe rescue rate （P＞0.05）. CONCLUSIONS： The intervention implemented by clinical pharmacists effectively reduce the utilization rate of antibiotics and the incidence of ADR， improve the rate of infection control， reduce antibiotics cost and the occurrence of irrational drug use. However， there are still some problems in respiratory department of our hospital， such as irrational drug use， nonstandard dosage， irrational drug combination and no etiological support， etc. Continuous follow-up intervention is needed. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 柴健，张洁 |
| AUTHORS： | CHAI Jian，ZHANG Jie |
| 关键字： | 呼吸内科；临床药师；抗菌药物；干预效果；合理用药 |
| KEYWORDS： | Respiratory department； Clinical pharmacist； Antibiotics； Intervention effect； Rational drug use |
| 阅读数： | 416 次 |
| 本月下载数： | 8 次 |
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