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心脉隆注射液联合曲美他嗪治疗冠心病慢性心力衰竭（气阳两虚证）的临床观察
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| 篇名： | 心脉隆注射液联合曲美他嗪治疗冠心病慢性心力衰竭（气阳两虚证）的临床观察 |
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| 摘要： | 目的：观察心脉隆注射液联合曲美他嗪治疗冠心病慢性心力衰竭（气阳两虚证）患者的临床疗效及安全性。方法：选取我院2011年1月－2015年12月收治的冠心病慢性心力衰竭（气阳两虚证）患者80例，按随机数字表法分为观察组和对照组，各40例。两组患者均给予常规治疗，对照组在常规治疗基础上加用盐酸曲美他嗪片20 mg，tid，连续治疗6个月；观察组患者在对照组基础上加用心脉隆注射液5 mg/kg加入0.9％的氯化钠注射液500 mL中，ivgtt，bid，速度为30滴/min，2次间隔＞6 h，连续用药5 d。观察两组患者的心功能疗效、中医症候疗效及治疗前后左室射血分数（LVEF），并比较不良反应发生情况。结果：观察组患者心功能总有效率、中医症候总有效率分别为90.00％、95.00％，显著高于对照组的62.50％、55.00％，差异均有统计学意义（P＜0.05）。治疗前，两组患者LVEF水平比较，差异无统计学意义（P＞0.05）；治疗后，两组患者LEVF水平均显著升高，且观察组显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：心脉隆注射液联合曲美他嗪治疗冠心病慢性心力衰竭（气阳两虚证）疗效显著，能明显提高患者LVEF水平，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Xinmailong injection combined with trimetazidine in the treatment of chronic heart failure of coronary heart disease （CHD）（Qi Yang deficiency ）. METHODS： A total of 80 patients with Qi Yang deficiency chronic heart failure of CHD were selected from our hospital during Jan. 2011-Dec. 2105 were divided into observation group and control group according to random number table， with 40 cases in each group. Both groups received routine treatment. Control group was additionally given Trimetazidine dihydrochloride tablets 20 mg， tid， for consecutive 6 months， on the basis of routine treatment. Observation group was additionally given Xinmailong injection 5 mg/kg added into 0.9％ Sodium chloride injection 500 mL， ivgtt， at speed of 30 drops/min， bid， medication interval＞6 h， for consecutive 5 days， on the basis of control group. Efficacies of cardiac function improvement， TCM symptom efficacies as well as LVEF before and after treatment were observed in 2 groups. The occurrence of ADR was compared between 2 groups. RESULTS： Total response rates of cardiac function and TCM symptom were 90.00％ and 95.00％ in observation group， which were significantly higher than 62.50％ and 55.00％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in LVEF between 2 groups （P＞0.05）. After treatment， LEVF levels of 2 groups were increased significantly， and the observation group was significantly higher than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Xinmailong injection combined with trimetazidine in the treatment of Qi Yang deficiency chronic heart failure of CHD show significant therapeutic efficacy and improve LEVF level with good safety. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 腾名子，王晓彦 |
| AUTHORS： | TENG Mingzi，WANG Xiaoyan |
| 关键字： | 心脉隆注射液；曲美他嗪；冠心病慢性心力衰竭；气阳两虚证；疗效 |
| KEYWORDS： | Xinmailong injection； Trimetazidine； Chronic heart failure of coronary heart disease； Qi Yang-deficiency； Therapeutic efficacy |
| 阅读数： | 639 次 |
| 本月下载数： | 4 次 |
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