我院5 770份肠外营养医嘱药物稳定性和选药合理性分析
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篇名: 我院5 770份肠外营养医嘱药物稳定性和选药合理性分析
TITLE:
摘要: 目的:为肠外营养合理用药提供参考。方法:选取我院2015年5月-2016年4月5 770份肠外营养医嘱,结合患者营养状况、临床诊断和实验室检查,对其营养液的稳定性、选药合理性、药物经济性等进行综合分析。结果:5 770份肠外营养医嘱中,营养液稳定性合格率为89.46%;肝功能异常、肾功能异常、妊娠剧吐、胰腺炎、完全禁食、长期应用肠外营养(>14 d)和三酰甘油>4.5 mmol/L患者选药合理率分别为76.19%、63.16%、75.00%、78.95%、65.95%、64.06%和50.00%;作用相同、剂量相等、价格相差4~34倍的同类药物有4组,不合适选药率为7.58%~61.64% 。结论:肠外营养处方设计时,既要考虑患者营养状况、临床诊断、实验室检查指标等个体情况,又要考虑药物高效、安全、经济及整个营养液稳定性。
ABSTRACT: OBJECTIVE: To provide reference for rational use of parenteral nutrition.  METHODS: Combining with the patients’ nutritional status, clinical diagnosis and lab examination, 5 770 parenteral nutrition medical orders were collected from our hospital during May 2015-Apr. 2016, and then analyzed in respects of the stability of drug use, rationality of drug selection and  pharmacoeconomics. RESULTS: The qualified stability of nutrient solution in 5 770 parenteral nutrition medical orders accounted for 89.46%. The rates of reasonable drug selection in patients with abnormal liver function, renal function, hyperemesis gravidarum, pancreatitis, complete fasting, long term parenteral nutrition (>14 d) and triacylglycerol >4.5 mmol/L were 76.19%, 63.16%, 75.00%, 78.95%, 65.95%, 64.06% and 50.00%, respectively.  Four kinds of drugs were with same effect and dose, price difference between 4-34 times, the rate of inappropriate drug selection ranged 7.58%-61.64%. CONCLUSIONS: Parenteral nutrition design need to not only consider about nutritional status, clinical diagnosis and lab examination, but also take into account high efficiency, safety, economy and the stability of whole nutrient solution.
期刊: 2017年第28卷第20期
作者: 李尧,李晓明,宋艳梅,史英钦
AUTHORS: LI Yao,LI Xiaoming,SONG Yanmei,SHI Yingqin
关键字: 肠外营养;处方点评;临床诊断;药物经济学;稳定性
KEYWORDS: Parenteral nutrition; Prescription comments; Clinical diagnosis; Pharmacoeconomics; Stability
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