帕罗西汀对急性脑梗死后抑郁患者抑郁状态及神经功能恢复的影响-中国药房

帕罗西汀对急性脑梗死后抑郁患者抑郁状态及神经功能恢复的影响

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篇名：	帕罗西汀对急性脑梗死后抑郁患者抑郁状态及神经功能恢复的影响
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摘要：	目的：探讨帕罗西汀对急性脑梗死后抑郁患者抑郁状态及神经功能恢复的影响。方法：回顾性分析我院108例急性脑梗死后抑郁患者资料，按照用药不同分为观察组（54例）和对照组（54例）。两组患者均给予脱水、活血化瘀、抗凝、降纤等常规治疗。在此基础上，观察组患者给予盐酸帕罗西汀片20 mg，每天1次；对照组患者给予盐酸舍曲林片50 mg，每天1次。两组疗程均为4周。观察两组患者抑郁缓解情况和神经功能恢复情况，比较治疗前后汉密尔顿抑郁量表（HAMD）和改良的爱丁堡-斯堪的纳维亚卒中量表（MESSS）评分及不良反应发生情况。结果：观察组患者抑郁缓解总有效率（70.37％）和神经功能恢复总有效率（66.67％）均显著高于对照组（分别为38.89％、40.74％），差异均有统计学意义（P＜0.05）。治疗前，两组患者HAMD和MESSS评分比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者HAMD和MESSS评分均显著低于同组治疗前，且观察组显著低于同期对照组，差异均有统计学意义（P＜0.05）。治疗期间两组患者均未见明显不良反应发生。结论：帕罗西汀治疗急性脑梗死后抑郁疗效较好，可以有效缓解患者的抑郁症状，间接促进其神经功能的恢复，对急性脑梗死患者预后有积极作用，安全性亦较好。
ABSTRACT：	OBJECTIVE： To investigate the effects of paroxetine on depression symptoms and neurological function recovery in patients with post-stroke depression. METHODS： A total of 108 patients with post-stroke depression in our hospital were analyzed retrospectively and divided into observation group （51 cases） and control group （50 cases）. Both groups received routine therapy as dehydration， activating blood circulation to dissipate blood stasis， anticoagulation， defibringen. Based on it， observation group was additionally given Paroxetine hydrochloride tablet 20 mg， once a day； control group was additionally given Sertraline hydrochloride tablet 50 mg， once a day. Treatment courses of 2 groups lasted for 4 weeks. The depression symptom relief and the recovery of neurological function were observed in 2 groups before and after treatment. HAMD score and MESSS score were compared before and after treatment， and the occurrence of ADR was recorded during treatment. RESULTS： Total response rate of depression symptom relief （70.37％ vs. 38.89％） and the recovery of neurological function （66.67％ vs. 40.74％） in observation group were significantly higher than control group， with statistical significance（P＜0.05）. Before treatment， there was no statistical significance in HAMD score and MESSS score between 2 groups（P＞0.05）； after treatment， HAMD score and MESSS score of 2 groups were significantly lower than before treatment， and the observation group was significantly lower than the control group， with statistical significance（P＜0.05）. During treatment，no obvious ADR was found in 2 groups. CONCLUSIONS： Paroxetine has good therapeutic efficacy for post-stroke depression and can effectively relieve the depression so as to promote the recovery of neurological function， which has a positive effect on the prognosis of patients with acute cerebral infarction and doesn’t increase the occurrence of ADR with good safety.
期刊：	2017年第28卷第15期
作者：	雷旭珍，乔彦生
AUTHORS：	LEI Xuzhen，QIAO Yansheng
关键字：	帕罗西汀；急性脑梗死；抑郁；神经功能
KEYWORDS：	Paroxetine； Acute cerebral infarction； Depression； Neurological function
阅读数：	465 次
本月下载数：	4 次

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