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小柴胡汤对伊立替康致迟发性腹泻模型小鼠血便的防治作用
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| 篇名： | 小柴胡汤对伊立替康致迟发性腹泻模型小鼠血便的防治作用 |
| TITLE： | |
| 摘要： | 目的：考察小柴胡汤对伊立替康（CPT-11）致迟发性腹泻模型小鼠血便的防治作用。方法：将40只小鼠随机分为正常对照组（等体积生理盐水）、模型对照组（等体积生理盐水）、小柴胡汤组（1 500 mg/kg，以生药计）和洛哌丁胺组（阳性对照，0.533 3 mg/kg），ig给药，每天1次，连续17 d。于实验第4～10天，除正常对照组外，其余各组小鼠均ip CPT-11诱导迟发性腹泻。测定小鼠体质量变化、血便率并观察小鼠大肠、小肠黏膜组织病理改变。结果：给药17 d后，造模组小鼠的体质量较正常对照组均明显下降（P＜0.05），但小柴胡汤组小鼠体质量高于模型对照组（P＜0.05）。实验第11～17 天，小柴胡汤组和洛哌丁胺组小鼠血便率均显著低于模型对照组（P＜0.01），且小柴胡汤组小鼠血便率低于洛哌丁胺组（P＜0.05）。病理观察结果显示，模型对照组小鼠大肠和小肠黏膜上皮细胞伴明显弥漫性坏死脱落和炎症细胞浸润，给药组小鼠肠黏膜组织均趋于正常。结论：小柴胡汤能有效降低血便率、改善肠黏膜组织损伤，对CPT-11致小鼠血便具有防治作用，且效果优于阳性药物洛哌丁胺。 |
| ABSTRACT： | OBJECTIVE： To investigate the prevention and treatment effect of Xiaochaihu decoction on irinotecan （CPT-11）-induced bloodystool in model mice with delayed diarrhea. METHODS： 40 mice were randomly divided into normal control group （equal volume of normal saline）， model control group （equal volume of normal saline）， Xiaochaihu decoction group （1 500 mg/kg， calculated by crude drug） and loperamide group （positive control， 0.533 3 mg/kg）， ig， once a day， for 17 days. Except for normal control group， other groups were intraperitoneally injected CPT-11 to induce delayed diarrhea in 4th-10th day. Body mass changes， bloodystool rate of mice were determined， and pathological changes in large intestine and small intestine were observed. RESULTS： After 17 days of administration， compared with normal control group， the body mass in modeling groups was obviously declined （P＜0.05）， while body mass in Xiaochaihu decoction group was higher than model control group （P＜0.05）. In the 11th-17th day， bloodystool rate in Xiaochaihu decoction group and loperamide group were significantly lower than model control group （P＜0.01）， and bloodystool rate in Xiaochaihu decoction group was lower than loperamide group （P＜0.05）. Pathological results showed， obvious diffuse necrosis and inflammatory cell infiltration were observed in mucosal epithelial cells of large intestine and small intestine in model control group， and the intestinal mucosal tissue in administration groups tended to be normal. CONCLUSIONS： Xiaochaihu decoction can effectively reduce bloodystool rate， improve intestinal mucosa injury， and has prevention and treatment effect on CPT-11-induced bloodystool in mice， with superior effect to loperamide. |
| 期刊： | 2017年第28卷第13期 |
| 作者： | 周圆，杨光义，宛 蕾 |
| AUTHORS： | ZHOU Yuan，YANG Guangyi，WAN Lei |
| 关键字： | 小柴胡汤；伊立替康；迟发性腹泻；肠黏膜损伤；血便；小鼠 |
| KEYWORDS： | Xiaochaihu decoction； Irinotecan； Delayed diarrhea； Intestinal mucosa injury； Bloodystool； Mice |
| 阅读数： | 476 次 |
| 本月下载数： | 6 次 |
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