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巴曲酶治疗老年突发性耳聋的临床观察
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| 篇名： | 巴曲酶治疗老年突发性耳聋的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察巴曲酶治疗老年突发性耳聋的疗效和安全性。方法：102例老年突发性耳聋患者随机分为对照组（51例）和观察组（51例）。对照组患者给予银杏叶提取物注射液105 mg，静脉滴注+地塞米松磷酸钠注射液30 mg，静脉滴注+甲磺酸倍他司汀片6 mg，口服等常规治疗；观察组患者在对照组治疗的基础上给予巴曲酶注射液 10 BU，加入0.9％氯化钠注射液100 mL中，静脉滴注，1 h内滴注完，后隔天给予5 BU，加入0.9％氯化钠注射液100 mL中，静脉滴注，1 h内滴注完。两组均连用10 d。观察两组患者的临床疗效，听力恢复时间、耳闷消失时间、眩晕消失时间和耳鸣消失时间，治疗前后纯音听阈值、血浆比黏度（ns）、高切变率下全血黏度（nbh）、低切变率下全血黏度（nbl）、血细胞比容（HCT）、红细胞沉降率（ESR）、血浆纤维蛋白原（Fb）、内皮素（ET）和一氧化氮（NO）水平及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，听力恢复时间、耳闷消失时间、眩晕消失时间和耳鸣消失时间均显著短于对照组，差异均有统计学意义（P＜0.05或P＜0.01）。治疗前，两组患者纯音听阈值、ns、nbh、nbl、HCT、ESR、Fb、ET和NO水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者纯音听阈值、ns、nbh、nbl、HCT、ESR、Fb和ET 水平均显著低于同组治疗前，且观察组显著低于对照组；两组患者NO水平均显著高于同组治疗前，且观察组显著高于对照组，差异均有统计学意义（P＜0.01）。两组患者治疗期间均未见明显不良反应发生。结论：在常规治疗的基础上，巴曲酶治疗老年突发性耳聋疗效显著，可改善症状，促进局部血流动力学恢复，改善内耳微循环障碍，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of batroxobin in the treatment of senile sudden deafness. METHODS： Totally 102 senile patients with sudden deafness were randomly divided into control group （51 cases） and observation group （51 cases）. Control group was given routine treatment as Ginkgo biloba extract injection 105 mg+Dexamethasone sodium phosphate injection 30 mg+Methotrexate tablets 6 mg orally. Based on control group， observation group was additionally given Batroxobin injection 10 BU added into 0.9％ Sodium chloride injection 100 mL intravenously， running out within 1 h， every 2 days， and then given 5 BU added into 0.9％ Sodium chloride injection 100 mL intravenously， running out within 1 h. Both groups were treated for 10 d. Clinical efficacy， hearing recovery time， ear drowsiness disappearance time， dizziness disappearance time and tinnitus disappearance time of 2 groups were observed. The levels of pure tone threshold， plasma specific viscosity （ns）， high shear rate of whole blood viscosity （nbh）， low shear rate of whole blood viscosity （nbl）， hematocrit （HCT）， erythrocyte sedimentation rate （ESR）， Fb， endothelin （ET） and nitric oxide （NO） were observed before and after treatment as well as the occurrence of ADR. RESULTS： The total response rate of observation group was significantly higher than that of control group； hearing recovery time， ear drowsiness disappearance time， dizziness disappearance time and tinnitus disappearance time were significantly shorter than control group， with statistical significance （P＜0.05 or P＜0.01）. Before treatment， there was no statistical significance in the levels of pure tone threshold， ns， nbh， nbl， HCT， ESR， Fb， ET and NO between 2 groups （P＞0.05）. After treatment， the levels of pure tone threshold， ns， nbh， nbl， HCT， ESR， Fb and ET in 2 groups were significantly lower than before； the observation group was significantly lower than the control group. The levels of NO in 2 groups were significantly higher than before； the observation group was significantly higher than the control group， with statistical significance （P＜0.01）. During treatment， no obvious ADR was found in 2 groups. CONCLUSIONS： Based on routine treatment， batroxobin is effective in the treatment of sudden deafness in the elderly， can effectively relieve the symptoms， improve the recovery of local blood flow and inner ear microcirculation disturbance with good safety. |
| 期刊： | 2017年第28卷第12期 |
| 作者： | 别国梁，付丽萍 |
| AUTHORS： | BIE Guoliang，FU Liping |
| 关键字： | 老年突发性耳聋；巴曲酶；疗效；安全性；血流动力学；微循环 |
| KEYWORDS： | Senile sudden deafness； Batroxobin； Therapeutic efficacy； Safety； Hemodynamics； Microcirculation |
| 阅读数： | 478 次 |
| 本月下载数： | 4 次 |
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