围产期危重症患者药物治疗分析与药学监护
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篇名: 围产期危重症患者药物治疗分析与药学监护
TITLE:
摘要: 目的:探讨临床药师在围产期危重患者药物治疗中的作用。方法:临床药师参与4例围产期危重患者的药物治疗过程,结合妊娠期及妊娠后特殊的病理生理状况(如尿素循环障碍、血脂异常、严重感染和循环血容量不能快速恢复等),在权衡治疗矛盾的基础上,结合相关指南和文献在药物选择、用药时机、用药疗程、联合用药、剂量调整等方面,针对性地给出选用头孢呋辛、还原型谷胱甘肽、熊去氧胆酸等药物,及时停药或调整抗菌药物治疗方案等个体化用药建议,并行实验室指标检测及不良反应监测等药学监护。结果:医师采纳临床药师建议,4例患者病情均好转。结论:临床药师在参与围产期危重患者药物治疗的过程中,应选择安全、有效的治疗药物,并根据其临床症状及时调整用药方案;当用药安全性与药物有效性矛盾时,应充分权衡利弊,确保孕妇和胎儿的生命安全。
ABSTRACT: OBJECTIVE: To explore the role of clinical pharmacists in the treatment of critical patients at perinatal stage. METHODS: During the treatment process of 4 critical patients at perinatal stage, according to the patients’ special pathophysiologic status (such as urea cycle disorder, dyslipidemia, severe infection, can not recover circulating blood volume rapidly, etc.), weighing the order of priority, based on relevant guidelines and literatures, clinical pharmacists provided individual medication advices in respects of drug selection, medication timing, treatment course, drug combination and dosage adjustment, such as using cefuroxime, reduced glutathione, ursodesoxycholic acid, etc., stopping drugs timely or adjusting antibiotics therapy plan. They also provided pharmaceutical care as lab index determination and ADR monitoring. RESULTS: Physicians adopted clinical pharmacists’ advices, and then 4 critical patients were all recovered. CONCLUSIONS: During the treatment course of critical patients at perinatal stage, clinical pharmacists should select safe and effective drugs as much as possible and adjust therapy plan in time according to clinical symptoms. When the security runs counter to effectiveness, clinical pharmacists should fully weigh the advantages and disadvantages and guarantee the maximum safety of pregnant or delivery women and fetuses.
期刊: 2017年第28卷第11期
作者: 李莉霞,杜隽铭,陆晓彤
AUTHORS: LI Lixia,DU Junming,LU Xiaotong
关键字: 围产期;危重症患者;临床药师;药物治疗;药学监护
KEYWORDS: Perinatal stage; Critical patient; Clinical pharmacist; Drug therapy; Pharmaceutical care
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