均匀设计筛选吲哚美辛亲水凝胶贴剂的基质处方
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篇名: 均匀设计筛选吲哚美辛亲水凝胶贴剂的基质处方
TITLE:
摘要: 目的:筛选吲哚美辛亲水凝胶贴剂的基质处方。方法:以外观、初黏力、柔软性、保湿性为指标,利用混合水平的均匀设计筛选贴剂的基质处方,并进行验证试验和贴剂离体透皮试验评价贴剂质量。结果:优选基质处方为聚乙烯醇 7.686 g、聚乙烯吡咯烷酮9.662 g、甘油19.992 g、明胶9.999 g、羧甲基纤维素钠13.997 g、卡波姆3.000 g、羟丙甲基纤维素 1.500 g。所制贴剂表面平整光滑,基质均匀,色泽良好,黏附力较强,柔软性良好(失水率为11.9%);能缓慢释药48 h,离体透皮释放行为符合Higuchi动力学模型(R2=0.986 9)。结论:成功制得吲哚美辛亲水凝胶贴剂,其能缓控药物释放,性质良好。
ABSTRACT: OBJECTIVE: To screen the matrix formulation of Indomethacin hydrophilic gel patch. METHODS: Using appearance, adhesion, softness, moisture retention as indexes, mixed level of uniform design was used to screen matrix formulation of patch, verification test and in vitro transdermal test were used to evaluate the patch quality. RESULTS: Optimized matrix formulation was as follow as PVA of 7.686 g, PVP of 9.662 g, glyceryl of 19.992 g, gelatin of 9.999 g, CMC-Na of 13.997 g, carbomer of 3.000 g, HPMC of 1.500 g. The prepared patch had smooth surface, uniform matrix, good color, strong adhesion, good softness (water loss rate of 11.9%). It can be slowly released for 48 h. The in vitro transdermal release fitted the Higuchi model (R2= 0.986 9). CONCLUSIONS: Indomethacin hydrophilic gel patch is successfully prepared, which can slowly release drug with overall good quality.
期刊: 2017年第28卷第10期
作者: 谢伟杰,张永萍,徐剑
AUTHORS: XIE Weijie,ZHANG Yongping,XU Jian
关键字: 均匀设计;吲哚美辛;贴剂;基质处方;成型工艺
KEYWORDS: Uniform design; Indomethacin; Patch; Matrix formulation; Forming technology
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