豨莶草醇提物对多柔比星致小鼠慢性心肌损伤的保护作用
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篇名: 豨莶草醇提物对多柔比星致小鼠慢性心肌损伤的保护作用
TITLE:
摘要: 目的:探讨豨莶草(HS)醇提物对多柔比星(DOX)致小鼠慢性心肌损伤的影响。方法:将48只小鼠随机分为3组,即空白对照(Con)组小鼠每天ig 1次蒸馏水(2 mL/100 g),并每周ip 1次生理盐水,持续8周;DOX组小鼠每天ig 1次蒸馏水(2 mL/100 g),并每周ip 1次DOX(3 mg/kg),持续8周;DOX+HS醇提物组小鼠每天ig 1次HS(340 mg/kg),并每周ip 1次DOX(3 mg/kg),持续8周。给药结束后,测定小鼠体质量、心脏系数、心功能变化以及血清生化指标[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、肌酸磷酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)及总胆固醇(TC)]水平。结果:与Con组比较,DOX组小鼠体质量减轻(P<0.01);心脏系数升高(P<0.05);心率减慢、R波增高(P<0.05或P<0.01);血清中生化指标均有所升高,其中AST差异有统计学意义(P<0.01)。与DOX组比较,DOX+HS醇提物组小鼠心脏系数降低(P<0.01);心率增加(P<0.01);血清中生化指标均有所降低,其中CK、LDH、TC差异有统计学意义(P<0.01)。结论:HS醇提物对DOX致小鼠慢性心肌损伤有一定的保护作用。
ABSTRACT: OBJECTIVE: To explore the effects of extracts from Siegesbeckiae herba (HS) on doxorubicin (DOX)-induced chronic myocardial injury in mice. METHODS: 48 mice were randomly divided into 3 groups. Mice in blank control (Con) group received distilled water once every day, ig, and normal saline (2 mL/100 g) once every day, ip, for 8 weeks; mice in DOX mice received distilled water (2 mL/100 g) once every day, ig, and DOX (3 mg/kg) once every week, ip, for 8 weeks; mice in DOX+HS group received HS (340 mg/kg) once every day, ig, and DOX (3 mg/kg) once every week, ip, for 8 weeks. After administration, body mass, heart coefficient, cardiac function changes, serum biochemical index levels [alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine phosphokinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and total cholesterol (TC)] of mice were determined. RESULTS: Compared with Con group, body mass of mice in DOX group was decreased (P<0.01); heart coefficient was increased (P<0.05); heart rate slowed down, R-wave was increased (P<0.05 or P<0.01); serum biochemical indexed were increased, there was significant difference in AST (P<0.01). Compared with DOX group, heart coefficient of mice in DOX+HS group was decreased (P<0.01); heart rate was increased (P<0.01); serum biochemical indexes were decreased, there was significant differences in CK, LDH, TC (P<0.01). CONCLUSIONS: HS has certain protective effects on DOX-induced chronic myocardial injury in mice.
期刊: 2017年第28卷第10期
作者: 于静,苏素文,杨继章,何林峰,王可欣,张晓飞
AUTHORS: YU Jing,SU Suwen,YANG Jizhang,HE Linfeng,WANG Kexin,ZHANG Xiaofei
关键字: 豨莶草醇提物;多柔比星;慢性心肌损伤;小鼠
KEYWORDS: Ethanol extracts from Siegesbeckiae herba; Doxorubicin; Chronic myocardial injury; Mice
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