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复方川芎滴丸对糖尿病肾病模型大鼠血液流变学及血气的影响
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| 篇名： | 复方川芎滴丸对糖尿病肾病模型大鼠血液流变学及血气的影响 |
| TITLE： | |
| 摘要： | 目的：探讨复方川芎滴丸对糖尿病肾病（DN）模型大鼠血液流变学及血气的影响。方法：将60只大鼠随机分为正常对照组、模型组、阳性对照组[厄贝沙坦片，0.013 g/（kg·d）]和复方川芎滴丸高、中、低剂量组[0.4、0.2、0.1 g/（kg·d）]，每组10只。除正常对照组外，其余各组大鼠均以高糖高脂饲料+ip链脲佐菌素的方法复制DN模型。成模7 d后，各给药组大鼠每天ig 相应药物1次，10 mL/kg；正常对照组和模型组大鼠ig等体积纯化水。64 d后，测定大鼠血液流变学指标[全血黏度（高、中、低切）、血浆黏度、全血还原黏度]和血气指标（二氧化碳分压、氧分压、血红蛋白含量、氧饱和度、氧合血红蛋白占总蛋白的比例），苏木精-伊红染色观察大鼠肾组织病理变化。结果：与正常对照组比较，模型组大鼠血液流变学各指标和二氧化碳分压均明显升高（P＜0.05或P＜0.01），氧分压、血红蛋白含量、氧饱和度、氧合血红蛋白占总蛋白的比例均明显降低（P＜0.05或P＜0.01），肾组织损伤严重。与模型组比较，除复方川芎滴丸低剂量组大鼠二氧化碳分压、氧分压、血红蛋白含量改善不显著外，其余各给药组大鼠上述指标均显著改善（P＜0.05或P＜0.01），大鼠肾组织损伤也不同程度地减轻。结论：复方川芎滴丸可显著改善DN模型大鼠异常的血液流变学状态，降低血液黏度，改善微循环，提高血液运输氧的能力，且对DN大鼠的肾组织形态有一定的改善作用。 |
| ABSTRACT： | OBJECTIVE： To explore the effects of Compound Ligusticum chuanxiong drop pill on hemorheology and blood gas in model rats with diabetic nephropathy（DN）. METHODS：60 rats were randomly divided into normal control group， model group， positive control group [Irbesartan tablet， 0.013 g/（kg·d）] and Compound L. chuanxiong drop pill high-dose，medium-dose， low- dose groups [0.4，0.2，0.1 g/（kg·d）]，10 in each group. Except for normal control group， rats in other groups were given high-sugar high-fat feed and intraperitoneally injected streptozotocin to reduce DN model. After 7 d modeling，rats in each group received related drugs intragastrically， once a day，10 mL/kg； normal control group and model group received equal volume of purified water intragastrically. After 64 d， hemorheology indicators [whole blood viscosity（high-shear，medium-shear and low-shear）， plasma viscosity，whole blood reduced viscosity] and blood gas indicators（carbon dioxide partial pressure，oxygen partial pressure， hemoglobin content， oxygen saturation， ratio of oxygenated hemoglobin to total protein） of rats were determined， hematoxylin-eosin staining was used to observe the pathological changes in kidney tissue. RESULTS：Compared with normal control group，hemorheology indicators and carbon dioxide partial pressure in model group were significantly increased （P＜0.05 or P＜0.01）， oxygen partial pressure，hemoglobin content， oxygen saturation， ratio of oxygenated hemoglobin to total protein were significantly decreased （P＜0.05 or P＜0.01）， with severe kidney damage. Compared with model group， except the improvement of carbon dioxide partial pressure，oxygen partial pressure， hemoglobin content in rats were not significant in Compound L. chuanxiong drop pill low-dose group，the above-mentioned indicators in other medicine groups were significantly improved（P＜0.05 or P＜0.01）； the kidney tissue damage was improved to varying degree. CONCLUSIONS：Compound L. chuanxiong drop pill can significantly improve the hemorheology indicators of DN model rats，reduce blood viscosity，improve microcirculation and capacity of the blood to transport oxygen， and has certain improvement effect on kidney tissue morphology of DN rats. |
| 期刊： | 2017年第28卷第7期 |
| 作者： | 孙昕，刘卫 |
| AUTHORS： | SUN Xin，LIU Wei |
| 关键字： | 复方川芎滴丸；糖尿病肾病；血液流变学；血气；肾组织病理；大鼠 |
| KEYWORDS： | Compound Ligusticum chuanxiong drop pill； Diabetic nephropathy； Hemorheology； Blood gas； Kidney tissue pathology； Rats |
| 阅读数： | 268 次 |
| 本月下载数： | 3 次 |
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