红栀骨通凝胶膏对家兔皮肤刺激性的研究
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篇名: 红栀骨通凝胶膏对家兔皮肤刺激性的研究
TITLE:
摘要: 目的:研究红栀骨通凝胶膏经皮给药的安全性。方法:分别取家兔行完整皮肤单次给药刺激性实验(n=4)、破损皮肤单次给药刺激性实验(n=4)、完整皮肤多次给药刺激性实验(n=4)。各家兔左右两侧皮肤分别贴3 cm×3 cm空白基质和红栀骨通凝胶膏24 h(按生药计为0.14 g)。前2项实验家兔分别于去除胶布1、24、48、72 h后观察去毛部位的红斑和水肿情况;第3项实验家兔给药24 h后,暴露给药区域1 h后再次给药,重复3次,分别观察第1、2次去除胶布后及第3次去除胶布1、24、48、72 h后去毛部位的红斑和水肿情况。结果:3项实验中,各组家兔的红斑和水肿评分均为0分,皮肤刺激性均评价为无刺激。结论:红栀骨通凝胶膏对家兔皮肤无刺激性。
ABSTRACT: OBJECTIVE: To study the safety of percutaneous administration of Hongzhi gutong cataplasm. METHODS: Rabbits were taken for single dose in complete skin irritation test (n=4), single dose in damaged skin irritation test (n=4) and multiple doses in complete skin irritation test (n=4). The left and right sides of the skin respectively paste 3 cm×3 cm blank matrix and Hongzhi gutong cataplasm for 24 h (calculated by crude drug of 0.14 g). After removing tape 1, 24, 48, 72 h, the erythema and edema in hair removal site of rabbits in the former 2 tests were observed; after 24 h of administration, the rabbits in the last group were administrated again after exposing the administration area for 1 h, repeated 3 times, the erythema and edema in hair removal site after removing tape the first, second time and 1, 24, 48, 72 h in the third time were respectively observed. RESULTS: In the 3 experiments, the scores of erythema and edema of all rabbits were 0, and skin irritation was evaluated as no irritation. CONCLUSIONS: Hongzhi gutong cataplasm has no skin irritation in rabbits.
期刊: 2017年第28卷第7期
作者: 彭伟文,王珠强,吴飞
AUTHORS: PENG Weiwen,WANG Zhuqiang,WU Fei
关键字: 红栀骨通凝胶膏;皮肤刺激性;完整皮肤;破损皮肤;单次给药;多次给药;家兔
KEYWORDS: Hongzhi gutong cataplasm; Skin irritation; Complete skin; Damaged skin; Single dose; Multiple doses; Rabbits
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