我院2013-2015年慢性阻塞性肺疾病急性加重期抗菌药物利用评价
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篇名: 我院2013-2015年慢性阻塞性肺疾病急性加重期抗菌药物利用评价
TITLE:
摘要: 目的:评价慢性阻塞性肺疾病急性加重期(AECOPD)住院患者使用抗菌药物的有效性、安全性和经济性,以促进抗菌药物的合理使用。方法:采用回顾性研究方法,以2013-2015年度为评价时间段,以主要诊断为AECOPD的住院患者为研究对象,评价其抗菌药物利用情况。结果:纳入本研究的AECOPD患者共3 186人次,抗菌药物使用率在90%以上。注射用头孢地嗪钠的用药频度(DDDs)在3年中连续排在第1位,但在2015年有所下降;而含酶的β-内酰胺类和碳青霉烯类抗菌药物的DDDs有所上升。日均费用(DDC)以注射用美罗培南和注射用亚胺培南西司他丁钠最高。药物利用指数(DUI)远大于1.0的有注射用头孢地嗪钠,远小于1.0的有注射用哌拉西林钠舒巴坦钠。注射用头孢地嗪钠的排序比(B/A)在3年中都介于1~2之间,注射用哌拉西林钠舒巴坦钠、注射用亚胺培南西司他丁钠、注射用美罗培南的B/A都小于1.0。结论:我院AECOPD患者的抗感染治疗适应证掌握较为严格,抗菌药物使用率在逐年下降,抗菌药物的品种选择较为合理,药物利用基本合理的抗菌药物数量在逐年增加,但注射用头孢地嗪钠、注射用哌拉西林钠舒巴坦钠的药物利用合理性还有待提高。
ABSTRACT: OBJECTIVE: To evaluate the effectiveness, safety and economics of antibiotics for inpatients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD), in order to promote rational use of antibiotics. METHODS: In retrospective study, AECOPD inpatients were selected as research objects during 2013-2015 to evaluate the use of antibiotics. RESULTS: Three thousand one hundred and eighty-six AECOPD patients were enrolled in the study, and utilization ratio of antibiotics was above 90%. DDDs of Cefordizime sodium  for injection ranked the first place in 3 years and was decreased in 2015, while those of β-lactam and carbapenems were increased. DDC of Meropenem for injection and Imipenem/cilastatin sodium for injection were the highest. Drug utilization index (DUI) of Cefodizime for injection was far more than 1.0, while DUI of Piperacillin sodium and sulbactam sodium for injection was much less than 1.0. Sort ratio (B/A) of Cefodizime sodium for injection ranged 1-2 in 3 years. B/A of Piperacillin sodium and sulbactam sodium for injection, Imipenem and cilastatin sodium for injection, Meropenem for injection were lower than 1.0. CONCLUSIONS: The indication of anti-infective treatment in AECOPD patients have been mastered strictly in our hospital; the utilization ratio of antibiotics is decreased year by year; the types of antibiotics are rational relatively, and the number of antibiotics which is rationally used is increased year by year. But the rationality of Cefodizime sodium for injection and Piperacillin sodium/sulbactam sodium for injection need to be improved.
期刊: 2017年第28卷第5期
作者: 贺筱彬,林小华,刘舜莉,欧焕娇
AUTHORS: HE Xiaobin,LIN Xiaohua,LIU Shunli,OU Huanjiao
关键字: 慢性阻塞性肺疾病急性加重期;药物流行病学;药物利用评价
KEYWORDS: AECOPD; Drug epidemiology; Drug use evaluation
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