重组人干扰素α-2b治疗宫颈糜烂合并人乳头瘤病毒感染的临床观察
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篇名: 重组人干扰素α-2b治疗宫颈糜烂合并人乳头瘤病毒感染的临床观察
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摘要: 目的:观察重组人干扰素α-2b治疗宫颈糜烂合并人乳头瘤病毒(HPV)感染的疗效和安全性。方法:81例宫颈糜烂合并HPV感染患者随机分为对照组(40例)和观察组(41例)。两组患者均于月经干净后3~7 d行微波治疗,微波治疗后3 d,对照组患者给予保妇康栓剂1粒,睡前置于阴道深部,每日1次,连用14 d。观察组患者在对照组治疗的基础上给予重组人干扰素α-2b凝胶1 g,每日1次,连用14 d。观察两组患者的临床疗效,HPV转阴率,治疗前后特异性转录因子(T-bet、GATA3、T-bet/GATA3、FoxP3)水平、炎症因子[白细胞介素(IL)-2、γ干扰素(IFN)-γ、 IL-4、IL-10、转化生长因子(TGF)-β1、IFN-γ/IL-4]水平及不良反应发生情况。结果:观察组患者总有效率、HPV转阴率均显著高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者T-bet、T-bet/GATA3、IL-2、IFN-γ、IFN-γ/IL-4水平均显著高于同组治疗前,且观察组显著高于对照组;两组患者GATA3、FoxP3、IL-4、IL-10、TGF-β1水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论: 在常规治疗的基础上,重组人干扰素α-2b治疗宫颈糜烂合并HPV感染的疗效和安全性均较好,可提高HPV转阴率。
ABSTRACT: OBJECTIVE: To observe the efficacy and safety of recombinant human interferon α-2b in the treatment of cervical erosion combined with human papillomavirus (HPV) infection. METHODS: 81 patients with cervical erosion combined with HPV infection were randomly divided into control group (40 cases) and observation group (40 cases). All patients received microwave therapy after 3-7 d of menstruation, control group was given Baofukang suppository 1 granule in deep vagina before going to bed after 3 d, once a day, for 14 d. Observation group was additionally given Recombinant human interferon α-2b gel 1 g, once a day, for 14 d. The clinical efficacy, HPV negative conversion rate, specific transcription factor levels (T-bet, GATA3, T-bet/GATA3, FoxP3), inflammatory cytokine levels [interleukin (IL)-2, gamma interferon (IFN)-γ, IL-4, IL-10, transforming growth factor-β1(TGF-β1), IFN-γ/IL-4] before and after treatment, and the incidence of adverse reactions in 2 groups were observed. RESULTS: The total effective rate and HPV negative conversion rate in observation group were significantly higher than control group, with statistical significances (P<0.05). After treatment, T-bet, T-bet/GATA3, IL-2, IFN-γ, IFN-γ/IL-4 levels in 2 groups were significantly higher than before, and observation group was higher than control group; GATA3, FoxP3, IL-4, TGF-β1 levels were significantly lower than before, and observation group was lower than control group, with statistical significances (P<0.05). And there was no significant difference in the incidence of adverse reactions in 2 groups (P>0.05). CONCLUSIONS: Based on conventional treatment, recombinant human interferon α-2b has good efficacy and safety in the treatment of cervical erosion combined with HPV infection, increase the removal of the HPV.
期刊: 2017年第28卷第3期
作者: 蒋晓蓉,孟以秀,彭玲
AUTHORS: JIANG Xiaorong,MENG Yixiu,PENG Ling
关键字: 重组人干扰素α-2b;宫颈糜烂;人乳头瘤病毒;疗效;安全性;特异性转录因子;炎症因子
KEYWORDS: Recombinant human interferon α-2b; Cervical erosion; Human papillomavirus; Efficacy; Safety; Specific transcription factor; Imflammatory cytokine
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