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疏肝益阳胶囊治疗勃起功能障碍的作用机制及临床研究进展
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| 篇名： | 疏肝益阳胶囊治疗勃起功能障碍的作用机制及临床研究进展 |
| TITLE： | Mechanism of action and clinical research progress of Shugan yiyang capsule in the treatment of erectile dysfunction |
| 摘要： | 勃起功能障碍（ED）是严重危害男性身心健康、降低生活质量的常见慢性男科疾病。疏肝益阳胶囊为临床治疗ED的中药复方，具备疏肝解郁、活血补肾的核心功效。本文系统归纳梳理了疏肝益阳胶囊治疗ED的作用机制与临床研究现状，证实该药可通过调控一氧化氮合酶/环磷酸鸟苷、磷脂酰肌醇3-激酶/蛋白激酶B信号通路，抑制5型磷酸二酯酶（PDE-5）表达与氧化应激，调节下丘脑-垂体-睾丸轴功能，改善阴茎血流动力学，从而发挥治疗作用。在临床应用方面，疏肝益阳胶囊单独应用可改善ED患者的勃起功能及相关临床指标，与PDE-5抑制剂或外科手术联合应用亦表现出一定的协同增效作用，且临床耐受性良好。当前研究仍存在复方药效物质基础研究不足，作用通路间交互机制尚未充分阐明，部分潜在机制缺乏直接实验验证，以及临床研究样本量较小、证据等级有限等问题。未来应结合血清药物化学、多组学及药代动力学技术等深入解析其入血成分、关键药效组分及多靶点协同机制，同时开展多中心、大样本、长随访的随机对照试验，以提高临床证据质量，推动疏肝益阳胶囊治疗ED的精准应用。 |
| ABSTRACT： | Erectile dysfunction （ED） is a common chronic andrological disease that seriously impairs men’s physical and mental health and reduces their quality of life. Shugan yiyang capsule is a compound formula of traditional Chinese medicine for the clinical treatment of erectile dysfunction， with core effects of soothing the liver， relieving depression， promoting blood circulation， and nourishing the kidneys. This paper systematically reviewed the mechanisms of action and clinical research progress of Shugan yiyang capsule in the treatment of ED. Accumulated evidence indicated that this capsule exerted its therapeutic effects by modulating signaling pathways such as nitric oxide synthase/cyclic guanosine monophosphate and phosphoinositide 3-kinase/protein kinase B， inhibiting phosphodiesterase-5 （PDE-5） expression and oxidative stress， regulating hypothalamic-pituitary-testicular axis function， and improving penile hemodynamics. In terms of clinical application， Shugan yiyang capsule used alone improved erectile function and related clinical indicators in patients with ED. When combined with PDE-5 inhibitors or surgical operation， Shugan yiyang capsule also demonstrated certain synergistic and efficacy-enhancing effects， with generally good tolerability. However， existing studies were still limited by insufficient investigation of the pharmacodynamic material basis of the formula， inadequate elucidation of the interactions among different signaling pathways， a lack of direct experimental validation for some potential mechanisms， and relatively small sample sizes and limited levels of clinical evidence. Future studies will integrate serum pharmacochemistry， multi-omics approaches， and pharmacokinetic techniques to further characterize the absorbed constituents， key pharmacologically active components， and multi-target synergistic mechanisms of Shugan yiyang capsule. Meanwhile， multicenter， large-sample randomized controlled trials with long-term follow-up will be conducted to strengthen the quality of clinical evidence and facilitate the precise use of Shugan yiyang capsule in the treatment of ED. |
| 期刊： | 2026年第37卷第19期 |
| 作者： | 李胜男；仲崇副；陈腾飞；陈洪延 |
| AUTHORS： | LI Shengnan，ZHONG Chongfu，CHEN Tengfei，CHEN Hongyan |
| 关键字： | 疏肝益阳胶囊;勃起功能障碍;作用机制;临床应用 |
| KEYWORDS： | Shugan yiyang capsule;Erectile dysfunction;Mechanism of action;Clinical application |
| 阅读数： | 8 次 |
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