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柴胡加龙骨牡蛎汤治疗神经系统疾病的临床应用及作用机制研究进展
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| 篇名： | 柴胡加龙骨牡蛎汤治疗神经系统疾病的临床应用及作用机制研究进展 |
| TITLE： | Research progress on the clinical application and mechanism of Chaihu jia longgu muli decoction in the treatment of neurological diseases |
| 摘要： | 神经系统疾病发病率、致残率高，对人类健康构成了严峻威胁，临床表现为运动、感觉、认知及意识障碍等症状。柴胡加龙骨牡蛎汤源于《伤寒论》，具有和解少阳、通阳泄热、重镇安神的功效。本文系统综述了柴胡加龙骨牡蛎汤在神经系统疾病领域的临床应用及作用机制研究进展，发现其在失眠、抑郁、癫痫、眩晕、偏头痛、血管性痴呆等多种神经系统疾病中展现出良好疗效，具体作用机制与调节神经递质水平、修复神经元功能、减轻神经炎症、改善线粒体功能障碍、调节肠道菌群有关。未来应建立标准的前瞻性随访队列，明确观察指标以夯实循证依据，依托多学科研究拓展柴胡加龙骨牡蛎汤在神经系统疾病中的应用价值。 |
| ABSTRACT： | Neurological diseases have high morbidity and disability rates， posing a severe threat to human health. Cli nical manifestations include motor， sensory， cognitive and conscious disorders. Chaihu jia longgu muli decoction is derived from Treatise on Febrile Diseases ， with the effects of harmonizing Shaoyang， activating Yang and clearing heat， and tranquilizing the mind. This paper systematically reviews the research progress in clinical application and mechanism of Chaihu jia longgu muli decoction in the field of neurological diseases. It has been found that the decoction shows favorable efficacy in various neurological diseases such as insomnia， depression， epilepsy， vertigo， migraine and vascular dementia. The specific mechanisms are related to regulating neurotransmitter levels， repairing neuronal function， alleviating neuroinflammation， improving mitochondrial dysfunction and regulating intestinal flora. In the future， standardized prospective follow-up cohorts should be established， and core outcome indicators should be clearly defined to strengthen the evidence base. Furthermore， multidisciplinary research should be leveraged to expand the therapeutic value of Chaihu jia longgu muli decoction in the management of neurological diseases. |
| 期刊： | 2026年第37卷第11期 |
| 作者： | 孔怡梦；刘志勇；段成思；史兰云；赵梅娜；张盟苑；杨晨 |
| AUTHORS： | KONG Yimeng，LIU Zhiyong，DUAN Chengsi，SHI Lanyun，ZHAO Meina，ZHANG Mengyuan，YANG Chen |
| 关键字： | 柴胡加龙骨牡蛎汤; 神经系统疾病; 临床应用; 作用机制 |
| KEYWORDS： | Chaihu jia longgu muli decoction; neurological diseases; clinical application; mechanism of action |
| 阅读数： | 32 次 |
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