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七福饮治疗髓海不足型阿尔茨海默病的研究进展
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| 篇名： | 七福饮治疗髓海不足型阿尔茨海默病的研究进展 |
| TITLE： | Research progress of Qifu yin in the treatment of Alzheimer’s disease with marrow-sea insufficiency syndrome |
| 摘要： | 阿尔茨海默病（AD）是一种与年龄密切相关的神经退行性疾病，其中髓海不足型AD为发病基础，早期对其进行辨证干预有助于延缓病程、改善患者认知功能。七福饮是AD髓海不足型的代表专用方剂。现有研究表明，七福饮可通过抑制β‑淀粉样蛋白异常沉积与tau蛋白过度磷酸化、减轻神经炎症、调控氧化应激与线粒体功能损伤、调节胆碱能系统、改善突触可塑性等多途径发挥神经保护作用。七福饮联合多奈哌齐、美金刚、丁苯酞等西药，或联合针灸等外治法，可有效改善AD患者认知功能与日常生活能力，且安全性良好。未来研究应聚焦髓海不足型AD的核心病机与关键靶点，深入阐释七福饮“补肾生髓”的科学内涵，并进一步开展高质量临床研究，为髓海不足型AD的防治提供科学依据。 |
| ABSTRACT： | Alzheimer’s disease （AD） is an age-related neurodegenerative disorder. Marrow-sea insufficiency serves as the fundamental basis for the onset of AD. Early syndrome differentiation-based intervention helps to delay disease progression， and improve patients’ cognitive function. Qifu yin is a representative specialized prescription for AD with marrow-sea insufficiency syndrome. Studies demonstrate that Qifu yin exerts neuroprotective effects through multiple pathways， including inhibiting the abnormal deposition of amyloid β -protein and hyperphosphorylation of tau protein， alleviating neuroinflammation， regulating oxidative stress and mitochondrial dysfunction， modulating the cholinergic system， and improving synaptic plasticity. Qifu yin combined with Western medicine such as donepezil， memantine， and butylphthalide， or combined with external therapies such as acupuncture， can effectively improve cognitive function and activities of daily living in AD patients with favorable safety. Future research should focus on the core pathogenesis and key targets of AD with marrow-sea insufficiency syndrome， provide in-depth elucidation of the scientific connotation of Qifu yin’s “tonifying the kidney to produce marrow”， and further conduct high-quality clinical studies to provide scientific evidence for the prevention and treatment of AD with marrow-sea insufficiency syndrome. |
| 期刊： | 2026年第37卷第10期 |
| 作者： | 魏子龙；赵晨怡；乔明亮；王弘玮；朱沛；孟毅 |
| AUTHORS： | WEI Zilong，ZHAO Chenyi，QIAO Mingliang，WANG Hongwei，ZHU Pei，MENG Yi |
| 关键字： | 七福饮；阿尔茨海默病；髓海不足型；作用机制；临床研究 |
| KEYWORDS： | Qifu yin； Alzheimer’s disease； marrow-sea insufficiency； mechanism of action； clinical research |
| 阅读数： | 10 次 |
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