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儿童口服用药特点及新剂型研究进展
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| 篇名： | 儿童口服用药特点及新剂型研究进展 |
| TITLE： | Characteristics of pediatric oral dosing and research progress in new dosage forms |
| 摘要： | 儿童是一个特殊的用药群体，其解剖、生理及心理特征均与成人存在较大差异，研发适合儿童特点的口服药物新剂型面临诸多挑战。适合儿童口服剂型种类少、规格单一，无法满足儿童临床用药需求。近年来，微型口崩片、微片、口溶膜、口服多微粒型制剂、口服粉剂、咀嚼胶囊等儿童用新剂型已获批上市，展现出明显临床优势。含药果冻、含药奶粉、口服凝胶、不含防腐剂的单剂量口服液体制剂，以及用前可重构成口服液体制剂的单剂量固体制剂等新剂型，可能是未来儿童口服制剂的重要补充。此外，一些儿童口服给药装置的出现，也为方便儿童用药和保证给药剂量的准确性提供了有利条件。 |
| ABSTRACT： | Children are a specific population of drug use and there exist obvious differences in anatomy， physiology and psycholo gy between children and adults. The development of child-appropriate oral dosage forms faces many challenges. Few types and specifications of oral dosage forms suitable for pediatric use lead to failure to meet the clinical need for pediatric dosing. In recent years， some child-appropriate new dosage forms， such as orodispersible mini-tablets， micro-tablets， oral dispersible films， oral multi-particulate dosage forms， oral powder， and chewable capsules， have been approved for marketing and further exhibit obvious clinical advantages. Meanwhile， other new pediatric oral preparations， such as drug-containing oral jelly， drug-containing milk powder， oral gel， preservative-free single-dose oral liquid preparations， and single-dose oral solid preparations that need to be reconstituted into liquid before use， may become an important supplement to pediatric oral preparations in the future. Additionally， the emergence of some new pediatric oral dosing devices will also provide a strong guarantee for convenient and accurate dosing in children. |
| 期刊： | 2026年第37卷第08期 |
| 作者： | 谷福根 |
| AUTHORS： | GU Fugen |
| 关键字： | 口服给药；儿童；特殊人群；新剂型；用药依从性；给药装置 |
| KEYWORDS： | oral dosing； children； special population； new dosage forms； compliance； dosing device |
| 阅读数： | 10 次 |
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