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天然活性成分通过HIF-1α干预椎间盘退变“缺氧-焦亡-炎症”级联反应的研究进展
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| 篇名： | 天然活性成分通过HIF-1α干预椎间盘退变“缺氧-焦亡-炎症”级联反应的研究进展 |
| TITLE： | Research progress on natural active ingredients intervening in the hypoxia-pyroptosis-inflammation cascade in intervertebral disc degeneration through HIF-1α |
| 摘要： | 椎间盘退变（IVDD）是慢性下腰痛的核心病因，可严重降低患者的生活质量，并造成沉重的社会医疗负担。缺氧诱导因子1α（HIF-1α）介导的“缺氧-焦亡-炎症”级联反应是驱动IVDD发生发展的核心病理机制。中药来源的天然活性成分因多靶点作用、疗效显著、低毒性等优势，已成为IVDD防治领域的研究热点。本文系统综述了HIF-1α介导退变髓核组织“缺氧-焦亡-炎症”级联反应的机制及相关天然活性成分的干预作用，发现黄芩素、姜黄素、白藜芦醇等天然活性成分，可分别从靶向HIF-1α氧感知通路以阻断焦亡病理级联启动、抑制核苷酸结合结构域富含亮氨酸重复序列和含热蛋白结构域受体3炎症小体活化以切断炎症信号级联放大、干预消皮素D介导的焦亡执行阶段以保护细胞膜完整性、促进细胞外基质修复与基质稳态重建四个核心环节，多靶点干预HIF-1α介导的病理级联反应，从而延缓IVDD进展。 |
| ABSTRACT： | Intervertebral disc degeneration （IVDD） is the core cause of chronic low back pain， which severely impairs patients’ quality of life and imposes a heavy social and medical burden. The hypoxia-pyroptosis-inflammation cascade mediated by hypoxia-inducible factor-1α （HIF-1α） is the core pathological mechanism driving the initiation and progression of IVDD. Natural active ingredients derived from traditional Chinese medicine （TCM） have become a research hotspot in the field of IVDD prevention and treatment due to their advantages of multi-target effects， favorable efficacy， and low toxicity. This paper systematically reviews the mechanism of HIF-1α-mediated hypoxia-pyroptosis-inflammation cascade in degenerative nucleus pulposus tissue and the intervention of related active ingredients. It is found that natural active ingredients such as baicalein， curcumin and resveratrol can intervene in the HIF-1α-mediated pathological cascade through four core links to delay IVDD progression： targeting the HIF-1α oxygen sensing pathway to block the initiation of pyroptosis cascade， inhibiting NOD-like receptor protein 3 inflammasome activation to cut off the cascade amplification of inflammatory signals， intervening in the Gasdermin D-mediated pyroptosis execution stage to protect cell membrane integrity， and regulating extracellular matrix metabolism to reconstruct intervertebral disc homeostasis. |
| 期刊： | 2026年第37卷第08期 |
| 作者： | 王浩；陈仁场；黄文浩；周冰倩；郑喜秋；王佳浩；李念虎；吴亚东 |
| AUTHORS： | WANG Hao， CHEN Renchang，HUANG Wenhao，ZHOU Bingqian，ZHENG Xiqiu，WANG Jiahao，LI Nianhu，WU Yadong |
| 关键字： | 缺氧诱导因子1α；天然活性成分；髓核组织；缺氧；焦亡；炎症 |
| KEYWORDS： | HIF-1α； natural active ingredients； nucleus pulposus tissue； hypoxia； pyroptosis； inflammation |
| 阅读数： | 9 次 |
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