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中医药通过“脑-肠轴”干预胃食管反流病伴睡眠障碍的研究进展
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| 篇名： | 中医药通过“脑-肠轴”干预胃食管反流病伴睡眠障碍的研究进展 |
| TITLE： | Research progress on the intervention of gastroesophageal reflux disease with sleep disorders through the “brain-gut axis”with traditional Chinese medicine |
| 摘要： | 胃食管反流病（GERD）与睡眠障碍的临床共病率高，二者通过“脑-肠轴”形成恶性循环，严重影响患者生活质量。中医药以“整体观念”和“辨证论治”为核心指导，具有多靶点、低副作用的治疗特色，可为临床提供多元化的干预方案。本文从“脑-肠轴”角度出发，通过综述GERD与睡眠障碍共病的关系、系统梳理中医药调控“脑-肠轴”干预该共病的相关研究发现“，脑-肠轴”可通过脑肠肽（含胃肠分泌素）分泌异常、肠道菌群失调等途径，参与GERD伴睡眠障碍的病理过程；紧扣“肝胃不和”“胃不和则卧不安”等核心病机，运用中药复方（四逆散合左金丸加减等）、中医外治疗法（背俞指针疗法等）及中西医结合治疗（加味柴胡桂枝干姜汤联合质子泵抑制剂等）等多种手段，可靶向调节“脑-肠轴”相关神经递质、胃肠激素、炎症因子水平及肠道菌群组成，从而实现对GERD与睡眠障碍的同步改善。 |
| ABSTRACT： | The comorbidity rate of gastroesophageal reflux disease （GERD） and sleep disorders is high， and the two form a vicious circle through the “brain-gut axis”， which seriously impacts the patients’ quality of life. Traditional Chinese medicine （TCM）， guided by the core principles of “holistic concept” and “syndrome differentiation and treatment”， features multi-targeted therapeutic effects with minimal side effects， offering diverse intervention options for clinical practice. From the perspective of the “brain-gut axis”， this article reviews the relationship between the comorbidity of GERD and sleep disorders and systematically examines relevant research findings on how TCM regulates the “brain-gut axis” to intervene in this comorbid condition. The study reveals that the “brain-gut axis” may participate in the pathological progress of GERD accompanied by sleep disorders through pathways such as abnormalities in the secretion of brain-gut peptides （including gastrointestinal secretin）， as well as intestinal dysbiosis. By closely focusing on core pathogenic mechanisms such as “disharmony between the liver and stomach” and “insomnia due to stomach disharmony”， various approaches can be employed， including TCM formulas （e.g.， modified Sini powder combined with Zuojin pills）， external TCM therapies （e.g.， back-shu point digital acupressure）， and integrated traditional Chinese and Western medicine treatments （e.g.， modified Chaihu guizhi ganjiang decoction combined with proton pump inhibitors）. These methods can regulate the levels of neurotransmitters， gastrointestinal hormones， inflammatory factors， and the composition of intestinal microbiota associated with the “brain-gut axis”， thereby achieving simultaneous improvement in both GERD and sleep disorders. |
| 期刊： | 2026年第37卷第06期 |
| 作者： | 滕泽众；黎丽群；谭金晶；谢胜；杨成宁 |
| AUTHORS： | TENG Zezhong，LI Liqun，TAN Jinjing，XIE Sheng，YANG Chengning |
| 关键字： | 胃食管反流病；睡眠障碍；共病；脑-肠轴；中药复方；中医外治疗法；中西医结合治疗 |
| KEYWORDS： | gastroesophageal reflux disease； sleep disorders； |
| 阅读数： | 9 次 |
| 本月下载数： | 1 次 |
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