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中药有效成分调节生物钟节律干预慢性心力衰竭能量代谢障碍的研究进展
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| 篇名： | 中药有效成分调节生物钟节律干预慢性心力衰竭能量代谢障碍的研究进展 |
| TITLE： | Research progress on the intervention of energy metabolism disorders in chronic heart failure by active ingredients of traditional Chinese medicine through regulating circadian rhythms |
| 摘要： | 慢性心力衰竭（CHF）的发生发展与心肌能量代谢障碍密切相关，这一病理过程显著影响患者预后。中医“天人相应“”子午流注”等时间医学理论与现代生物钟节律学说具有高度的内在一致性，为从时间维度理解并干预CHF提供了独特的理论框架。本文通过梳理相关文献，系统探讨生物钟对能量代谢的影响及中药有效成分干预CHF的潜在机制，并发现黄酮类（如川陈皮素）、生物碱类（如小檗碱）、多酚类（如白藜芦醇）等多种中药活性成分，能够通过调控CLOCK、BMAL1、PER、CRY等核心生物钟基因的表达与节律，改善线粒体功能，促进脂肪酸氧化，提高葡萄糖摄取和利用效率，维持代谢平衡，缓解心肌细胞的氧化应激与炎症反应，从而纠正能量代谢紊乱，改善心功能。进一步探究这些有效成分与生物钟系统之间的相互作用机制，有望为CHF的防治提供新的理论依据与潜在的干预策略。 |
| ABSTRACT： | The onset and progression of chronic heart failure （CHF） are closely associated with myocardial energy metabolism disorders， and this pathological process significantly affects patient prognosis. Traditional Chinese medicine （TCM）， grounded in time-based medical theories such as the correspondence between humans and nature and the theory of circadian flow of meridians （Ziwu Liuzhu）， exhibits intrinsic consistency with modern circadian rhythm theory， providing a unique theoretical framework for understanding and intervening in CHF from a temporal perspective. This article systematically explores the impact of circadian rhythms on energy metabolism and the potential mechanisms by which TCM active ingredients intervene in CHF through a review of relevant literature. It is found that various TCM active ingredients， including flavonoids （such as nobiletin）， alkaloids （such as berberine）， and polyphenols （such as resveratrol）， can improve mitochondrial function， promote fatty acid oxidation， enhance glucose uptake and utilization efficiency， maintain metabolic balance， and alleviate oxidative stress and inflammatory responses in myocardial cells by regulating the expression and rhythms of core circadian clock genes such as CLOCK， BMAL1， PER， and CRY. These actions thereby correct energy metabolism disorders and improve cardiac function. Further exploration of the interaction mechanisms between these components and the circadian rhythms holds promise for providing novel theoretical foundations and potential intervention strategies for the prevention and treatment of CHF. |
| 期刊： | 2026年第37卷第05期 |
| 作者： | 郭瑞齐；王苏童；吕朝晖；李颜；管仁伟；李晓 |
| AUTHORS： | GUO Ruiqi，WANG Sutong，LYU Zhaohui，LI Yan，GUAN Renwei，LI Xiao |
| 关键字： | 生物钟；慢性心力衰竭；能量代谢；中药；有效成分 |
| KEYWORDS： | circadian rhythms； chronic heart failure； |
| 阅读数： | 7 次 |
| 本月下载数： | 0 次 |
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