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细胞膜仿生纳米粒递送抗肿瘤天然产物的研究进展
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| 篇名： | 细胞膜仿生纳米粒递送抗肿瘤天然产物的研究进展 |
| TITLE： | Research progress on cell membrane biomimetic nanoparticles for delivery of antitumor natural products |
| 摘要： | 天然产物在抗肿瘤药物研发中展现出巨大潜力，但水溶性差、稳定性低、生物利用度低等问题限制了其临床应用。细胞膜仿生纳米粒作为一种新型药物递送系统，为突破天然产物递送瓶颈提供了新策略。本文系统综述了细胞膜仿生纳米粒的制备方法（如膜挤压法、超声融合法和微流控电穿孔法）及重要的表征手段（如粒径、Zeta电位及膜表面蛋白检测），重点阐述了不同来源的细胞膜仿生纳米粒在天然产物抗肿瘤递送中的应用。细胞膜仿生纳米粒赋予纳米粒独特的生物学功能，包括干细胞膜降低免疫原性、红细胞膜延长体内循环时间、肿瘤细胞膜促进同源靶向等。尽管如此，该技术仍面临规模化生产困难、成本高、表征手段有限等挑战。未来的研究需进一步优化相关工艺，以此推动细胞膜仿生纳米粒向临床转化，为天然产物抗肿瘤治疗提供一条高效、安全的递送新途径。 |
| ABSTRACT： | Natural products have shown great potential in the research and development of antitumor drugs. However， their clinical application is severely limited by inherent drawbacks such as poor water solubility， low stability， and low bioavailability. Cell membrane biomimetic nanoparticles， as a novel drug delivery system， have provided new strategies to overcome this bottleneck. This review systematically summarizes the preparation methods （e.g.， membrane extrusion， ultrasonic fusion， and microfluidic electroporation） and characterization techniques （e.g.， particle size， Zeta potential， and membrane surface protein detection） of cell membrane biomimetic nanoparticles， with a focus on the application of these derived from various sources in delivering antitumor natural products. Cell membrane biomimetic nanoparticles are endowed with unique biological functions， including low immunogenicity conferred by stem cell membranes， prolonged systemic circulation enabled by red blood cell membranes， and homologous targeting facilitated by tumor cell membranes. Despite these advancements， the technology still faces challenges such as difficulties in large-scale production， high costs， and limited characterization methods. Future research needs to further optimize the relevant processes to promote the clinical translation of cell membrane-biomimetic nanoparticles， thereby offering an efficient and safe novel delivery approach for antitumor therapy using natural products. |
| 期刊： | 2026年第37卷第04期 |
| 作者： | 孟路华；潘鸿；刘书环；申梦朦 |
| AUTHORS： | MENG Luhua，PAN Hong，LIU Shuhuan，SHEN Mengmeng |
| 关键字： | 细胞膜；仿生纳米粒；天然产物；抗肿瘤；药物递送系统 |
| KEYWORDS： | cell membrane； biomimetic nanoparticles； natural products； antitumor； drug delivery system |
| 阅读数： | 5 次 |
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