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中药调控cAMP信号通路干预脂质代谢治疗肥胖的研究进展
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| 篇名： | 中药调控cAMP信号通路干预脂质代谢治疗肥胖的研究进展 |
| TITLE： | Research progress on the intervention of traditional Chinese medicine in lipid metabolism for obesity treatment via cAMP signaling pathway |
| 摘要： | 肥胖是一种全球性的慢性疾病，脂肪组织的功能障碍是导致肥胖的原因之一。环磷酸腺苷（cAMP）信号通路作为调节脂质代谢的重要通路，在肥胖的发生发展中具有重要作用。黄酮类、木脂素类、酚类、萜类等多种中药单体及逍遥散、生脉散、泽泻汤等中药复方能够通过调节cAMP信号通路维持能量稳态、平衡脂肪组织功能、调节机体糖代谢、改善胰岛素抵抗及抑制炎症反应，干预脂质代谢进程，从而治疗肥胖。尽管大量基础研究已初步阐明中药通过cAMP信号通路干预肥胖的潜在机制，但临床转化研究仍显不足，亟需大样本、高质量的随机对照试验加以验证。 |
| ABSTRACT： | Obesity， a global chronic disease， is associated with adipose tissue dysfunction， which is one of the contributing factors to obesity. The cyclic adenosine monophosphate （cAMP） signaling pathway， a key regulator of lipid metabolism， plays a pivotal role in obesity development. Various of traditional Chinese medicine monomers， such as flavonoids， lignans， phenols， and terpenoids， as well as traditional Chinese medicine compound formulas like Xiaoyao powder， Shengmai powder， and Zexie decoction， can maintain energy homeostasis， balance adipose tissue function， regulate glucose metabolism， improve insulin resistance， and suppress inflammatory responses through cAMP signaling pathway regulation， thereby intervening in lipid metabolism for obesity treatment. Although a substantial amount of basic research has preliminarily elucidated the potential mechanisms by which traditional Chinese medicine intervenes in obesity through the cAMP signaling pathway， clinical translational research remains inadequate. There is an urgent need for large-sample， high-quality randomized controlled trials to validate these findings. |
| 期刊： | 2026年第37卷第04期 |
| 作者： | 张雨；王笑冉；付依萍；刘玉婷；赵全友；崔琳娜；苗明三 |
| AUTHORS： | ZHANG Yu，WANG Xiaoran，FU Yiping，LIU Yuting，ZHAO Quanyou，CUI Linna，MIAO Mingsan |
| 关键字： | 肥胖；脂质代谢；cAMP信号通路；机制；中药 |
| KEYWORDS： | obesity； lipid metabolism； cAMP signaling pathway； mechanism； traditional Chinese medicine |
| 阅读数： | 3 次 |
| 本月下载数： | 0 次 |
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