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中药调节辅助性T细胞分化治疗脓毒症的研究进展
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| 篇名： | 中药调节辅助性T细胞分化治疗脓毒症的研究进展 |
| TITLE： | Research progress on traditional Chinese medicine in the treatment of sepsis by regulating helper T cell differen-tiation |
| 摘要： | 脓毒症是一种由感染引发的全身炎症反应综合征，其高死亡率与免疫失衡密切相关，尤其是Th细胞亚群[Th1、Th2、Th17、调节性T细胞（Treg）]的分化失衡。近年来，中药凭借其多成分、多靶点的作用特性，在调控Th细胞分化与功能、纠正脓毒症免疫失衡中展现出独特优势，为脓毒症的免疫治疗提供了新思路。本文综述了黄芪、黄芩、黄连、大黄、灵芝、白果、肉苁蓉等中药单体及活性成分，傣百解醇提取物，以及活血化瘀类、通腑泻下类、温阳补气类、益气养阴类中药复方及制剂调控Th细胞分化治疗脓毒症的相关研究，结果显示，上述中药单体、活性成分、提取物、复方及制剂均能通过调节Th1/Th2、Th17/Treg平衡，靶向调控Th细胞亚群分化平衡，减轻炎症反应或改善免疫抑制状态，发挥对脓毒症的治疗作用。 |
| ABSTRACT： | epsis is a systemic inflammatory response syndrome triggered by infection， and its high mortality rate is closely associated with immune imbalance， particularly the imbalance in the differentiation of helper T cell （Th） cell subsets [Th1， Th2， Th17， regulatory T cell （Treg） ] . In recent years， traditional Chinese medicine （TCM）， with its characteristics of multi-component and multi-target actions， has demonstrated unique advantages in regulating Th cell differentiation and function， as well as correcting immune imbalances in sepsis， offering new perspectives for immunotherapy of sepsis. This review summarizes relevant studies on the regulation of Th cell differentiation for sepsis treatment by TCM monomers and active ingredients （such as Astragalus membranaceus ， Scutellaria baicalensis ， Coptis chinensis ， Rheum palmatum ， Ganoderma lucidum ， Ginkgo biloba ， and Cistanche deserticola ）， the alcohol extract of Dai Baijie， and TCM formulas and preparations categorized as blood-activating and stasis-removing， purgative and laxative， warming and tonifying yang， and tonifying qi and nourishing yin. The results indicate that these TCM monomers， active ingredients， extracts， formulas， and preparations can regulate the Th1/Th2 and Th17/Treg balance， target the differentiation balance of Th cell subsets， alleviate inflammatory responses， or improve immune suppression， thereby exerting therapeutic effects on sepsis. |
| 期刊： | 2026年第37卷第04期 |
| 作者： | 郭思含；苏和；张瑞芬；贾婷婷；张海荣；荣吉林太 |
| AUTHORS： | GUO Sihan，SU He，ZHANG Ruifen，JIA Tingting，ZHANG Hairong，RONG Jilintai |
| 关键字： | 脓毒症；辅助性T细胞；调节性T细胞；免疫平衡；中药；细胞分化 |
| KEYWORDS： | sepsis； helper T cell； regulatory T cells； immune balance； traditional Chinese medicine； cell differentiation |
| 阅读数： | 1 次 |
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