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ICU常用16种静脉用抗菌药物配伍稳定性研究
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| 篇名： | ICU常用16种静脉用抗菌药物配伍稳定性研究 |
| TITLE： | Study on the compatibility stability of 16 commonly used intravenous antibiotics in ICU |
| 摘要： | 目的 系统分析重症监护病房（ICU）常用抗菌药物的配伍稳定性，为临床合理用药提供循证依据。方法收集河北省人民医院合理用药监测系统中2024年1－12月的ICU用药数据，向河北省内重症医学及药学专家进行咨询，结合药品说明书、Micromedex、Trissel’sInjectableDrugHandbook、PubMed等数据库中的药物相容性检索结果，筛选ICU常用抗菌药物及其他静脉药物，对药物组合的理化稳定性进行分析；同时，采用Cytoscape3.10.2软件构建药物相容性网络互作图，对高风险药物进行识别。结果与结论本研究共收集到ICU常用的16种抗菌药物及65种静脉药物的904个两两配伍的药物组合，其中549个组合（60.7%）相容，88个组合（9.7%）不相容，82个组合（9.1%）证据矛盾，185个组合（20.5%）证据缺失。不相容性风险较高的药物主要包括注射用两性霉素B、注射用头孢他啶、注射用亚胺培南西司他丁钠、注射用头孢曲松钠、注射用盐酸万古霉素等。药物间的不相容性风险因素主要包括药物浓度、温度、混合速度、pH及药物化学结构等。临床使用时，应依据具体药物的相容性数据，合理选择药物与溶媒，并加强对药物相容性的研究与监测。 |
| ABSTRACT： | OBJECTIVE To systematically analyze the compatibility stability of commonly used intravenous antibiotics in the intensive care unit （ICU）， and to provide evidence-based support for rational clinical drug use. METHODS Medication data from the ICU of Hebei General Hospital between January and December 2024 were extracted from the Prescription Automatic Screening System. Commonly used intravenous antibiotics and other intravenous drugs in the ICU were selected through consultations with critical care and pharmacy experts in Hebei province， drug package inserts and compatibility information retrieved from Micromedex， Trissel’s Injectable Drug Handbook and PubMed. The physicochemical stability of drug combinations was analyzed. In addition， Cytoscape 3.10.2 software was used to construct a drug compatibility network for identifying high-risk drugs. RESULTS &CONCLUSIONS A total of 904 pairwise drug combinations involving 16 antibacterial agents and 65 intravenous drugs were collected. Among them， 549 combinations （60.7%） were compatible， 88 combinations （9.7%） were incompatible， 82 combinations （9.1%） had conflicting evidence， and 185 combinations （20.5%） lacked valid data support. High-risk combination drugs primarily involved Amphotericin B for injection， Ceftazidime for injection， Imipenem-cilastatin for injection， Ceftriaxone sodium for injection， Vancomycin hydrochloride for injection， etc. The main risk factors for drug-drug incompatibility included drug concentration， temperature， mixing rate， pH， and chemical structure. In clinical practice， drugs and diluents should be selected rationally based on specific compatibility data， and research and monitoring of drug compatibility should be further strengthened. |
| 期刊： | 2026年第37卷第04期 |
| 作者： | 张俐婷；杨浩天；于思奇；范理菊；安静 |
| AUTHORS： | ZHANG Liting，YANG Haotian，YU Siqi，FAN Liju，AN Jing |
| 关键字： | 抗菌药物；静脉药物；配伍稳定性；相容性；重症监护病房 |
| KEYWORDS： | antibiotics； intravenous drugs； compatibility stability； compatibility； intensive care unit |
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