返回 
加入收藏
乌灵胶囊联合氟西汀治疗青少年首发中重度抑郁伴失眠的疗效与安全性分析
x
请在关注微信后，向客服人员索取文件
| 篇名： | 乌灵胶囊联合氟西汀治疗青少年首发中重度抑郁伴失眠的疗效与安全性分析 |
| TITLE： | Efficacy and safety analysis of Wuling capsules combined with fluoxetine in the treatment of adolescents with first-episode moderate-to-severe depressive disorder accompanied by insomnia |
| 摘要： | 目的 探讨乌灵胶囊联合氟西汀治疗青少年首发中重度抑郁伴失眠的疗效与安全性。方法回顾性收集2022年6月至2025年5月本院收治的476例首发中重度抑郁伴失眠青少年患者的临床资料，根据初始治疗方案的不同分为对照组（241例，单用氟西汀治疗）和观察组（235例，乌灵胶囊联合氟西汀治疗）。比较两组患者治疗前及治疗第4、8周的抑郁程度（汉密尔顿抑郁量表17项、抑郁自评量表评分），睡眠质量（匹兹堡睡眠质量指数评分、入睡潜伏期、夜间觉醒次数、总睡眠时间、睡眠效率），血清神经内分泌指标（皮质醇）和炎症指标（C反应蛋白、白细胞介素6），治疗第8周的有效率，以及不良反应发生情况。结果治疗前，两组患者的抑郁程度、睡眠质量、血清神经内分泌和炎症指标比较，差异均无统计学意义（P＞0.05）；治疗第4、8周，两组患者上述指标均较同组治疗前显著改善，且观察组上述指标的改善均显著优于同期对照组（P＜0.05）；治疗第8周，观察组患者的有效率为90.21%，显著高于对照组的80.50%（P＜0.05）；两组患者恶心、头痛、乏力、口干、心悸的发生率及总不良反应发生率比较，差异均无统计学意义（P＞0.05）。结论乌灵胶囊联合氟西汀能够显著提高首发中重度抑郁伴失眠青少年患者的有效率，加速缓解抑郁症状，改善睡眠质量，并降低血清神经内分泌和炎症指标水平，且安全性良好。 |
| ABSTRACT： | OBJECTIVE To investigate the efficacy and safety of Wuling capsules combined with fluoxetine in the treatment of adolescents with first-episode moderate-to-severe depressive disorder accompanied by insomnia. METHODS The clinical data of 476 adolescents with first-episode moderate-to-severe depression accompanied by insomnia admitted to our hospital from June 2022 to May 2025， were retrospectively collected. According to the initial treatment regimen， patients were divided into a control group （241 cases， treated with fluoxetine alone） and an observation group （235 cases， treated with Wuling capsules combined with fluoxetine）. The depression severity （Hamilton Depression Rating Scale-17 Item and the Self-Rating Depression Scale scores）， sleep quality （Pittsburgh Sleep Quality Index score， sleep latency， wake after sleep onset， total sleep time， sleep efficiency）， serum neuroendocrine indicator （cortisol） and inflammatory markers （C-reactive protein， interleukin-6） were compared between the two groups before treatment and at 4th and 8th weeks of treatment. The effective rate at 8th weeks and the occurrence of adverse drug reactions （ADRs） were also compared between the two groups. RESULTS Before treatment， there were no significant differences in depression severity， sleep quality， serum neuroendocrine indicator， and inflammatory markers between the two groups （ P ＞0.05）. At 4th and 8th weeks， both groups showed significant improvement in these indicators compared to those before treatment， with the observation group demonstrating significantly greater improvement than the control group at the corresponding time points （ P ＜0.05）. At 8th week， the eff ective rate of the observation group was 90.21%， significantly higher than 80.50% in the control group （ P ＜0.05）. The incidence of nausea， headache， fatigue， dry mouth， and palpitations， as well as the total incidence of ADRs， did not differ significantly between the two groups （ P ＞0.05）. CONCLUSIONS Wuling capsules combined with fluoxetine can significantly improve the effective rate in adolescents with first-episode moderate-to-severe depression accompanied by insomnia， accelerate the relief of depressive symptoms， improve sleep quality， and reduce serum neuroendocrine indicator and inflammatory markers， with a favorable safety profile. |
| 期刊： | 2026年第37卷第04期 |
| 作者： | 何恋；舒燕萍；恽渊；莫芸；张乾 |
| AUTHORS： | HE Lian，SHU Yanping，YUN Yuan，MO Yun，ZHANG Qian |
| 关键字： | 乌灵胶囊；氟西汀；中重度抑郁；失眠；青少年 |
| KEYWORDS： | Wuling capsules； fluoxetine； moderate-to-severe depression； insomnia； adolescents |
| 阅读数： | 0 次 |
| 本月下载数： | 0 次 |
* 注：未经本站明确许可，任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作！
