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人脐带间充质干细胞干预神经退行性变性疾病的研究进展
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| 篇名： | 人脐带间充质干细胞干预神经退行性变性疾病的研究进展 |
| TITLE： | Research progress on the intervention of human umbilical cord mesenchymal stem cell in neurodegenerative disease |
| 摘要： | 人脐带间充质干细胞（hUC-MSC）作为一种细胞药物治疗策略，因其自我更新、多向分化及低免疫原性等优势，在神经退行性变性疾病（NDD）领域展现出显著的应用潜力。hUC-MSC主要通过归巢与分化、介导旁分泌与释放外泌体、免疫调节与抗炎等多重机制，有效干预阿尔茨海默病、帕金森病、肌萎缩侧索硬化、多发性硬化症等多种疾病模型的病理特征与神经功能。已开展的几项临床研究也初步验证了hUC-MSC的安全性与有效性。当前其研究仍面临免疫排斥反应尚需进一步观察、长期安全性有待评估、作用机制未完全阐明、临床试验推进缓慢等挑战。未来研究需构建hUC-MSC的药品化标准，深化其药理机制与临床试验，最终为NDD患者提供新的有效药物治疗选择。 |
| ABSTRACT： | Human umbilical cord mesenchymal stem cell （hUC-MSC） as a cell-based therapeutic strategy have demonstrated significant application potential in the field of intervention for neurodegenerative disease （NDD） due to their advantages such as self-renewal， multi-directional differentiation， and low immunogenicity. hUC-MSC effectively intervenes in the pathological features and neurological functions of various disease models such as Alzheimer disease， Parkinson’s disease， amyotrophic lateral sclerosis， and multiple sclerosis primarily through multiple mechanisms such as homing and differentiation， mediating paracrine actions and releasing exosomes， as well as immune regulation and anti-inflammation. Some clinical studies have also preliminarily verified their safety and effectiveness. Currently， its research still faces challenges such as immune rejection reactions requiring further observation， long-term safety needing evaluation， mechanisms of action not being fully elucidated， and slow progress in clinical trials. Future research needs to establish pharmaceutical standards for hUC-MSC， deepen their pharmacological mechanisms and clinical trials， ultimately providing new and effective drug treatment options for patients with NDD. |
| 期刊： | 2026年第37卷第03期 |
| 作者： | 徐红彩；许玉珉；刘诗雨；闫化雨；刘源；杨鑫；吴亚博 |
| AUTHORS： | XU Hongcai，XU Yumin，LIU Shiyu，YAN Huayu，LIU Yuan，YANG Xin，WU Yabo |
| 关键字： | 人脐带间充质干细胞；神经退行性变性疾病；阿尔茨海默病；帕金森病；肌萎缩侧索硬化症；多发性硬化；归巢；外泌体 |
| KEYWORDS： | human umbilical cord mesenchymal stem cell； neurodegenerative disease； Alzheimer disease； Parkinson’s disease； |
| 阅读数： | 10 次 |
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