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基于MAPK信号通路探讨中药抗鼻咽癌作用的研究进展
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| 篇名： | 基于MAPK信号通路探讨中药抗鼻咽癌作用的研究进展 |
| TITLE： | Research progress on the anti-nasopharyngeal carcinoma effect of traditional Chinese medicine based on MAPK signaling pathway |
| 摘要： | 鼻咽癌是起源于鼻咽部黏膜上皮的恶性肿瘤，近年来其发病率与死亡率持续上升，目前临床仍缺乏兼具良好疗效与安全性的治疗方案。丝裂原激活的蛋白激酶（MAPK）信号通路在细胞增殖、分化、凋亡及侵袭等生物学过程中起关键调控角色，参与鼻咽癌的发生进展，是抗鼻咽癌的重要靶点。本文系统综述了MAPK信号通路在鼻咽癌中的作用机制，以及中药活性成分和复方通过调控该通路发挥抗鼻咽癌作用的研究现状。结果显示，黄酮类（木犀草素、高丽槐素、黄芩素等）、生物碱类（苦木西定Ⅰ、汉防己甲素等）、萜类（补骨脂酚、斑蝥酸）等中药活性成分，以及中药复方（鼻咽解毒胶囊、益气解毒方）可通过调控MAPK信号通路，诱导鼻咽癌细胞自噬与凋亡、促进细胞焦亡、逆转耐药、阻断上皮-间质转化、减弱细胞干性、阻滞细胞周期等机制，从而多途径抑制鼻咽癌的发生发展。 |
| ABSTRACT： | Nasopharyngeal carcinoma （NPC） is a malignant tumor originating from the mucosal epithelium of the nasopharynx. In recent years， its incidence and mortality rates have shown a continuous upward trend， and there is still a lack of therapeutic regimens with both favorable efficacy and safety in clinical practice. Mitogen-activated protein kinase （MAPK） signaling pathway plays a key regulatory role in biological processes such as cell proliferation， differentiation， apoptosis and invasion. It is widely involved in the occurrence and progression of NPC， and serves as an important target in the research field of anti-NPC therapy. This article systematically elaborates on the mechanism of action of the MAPK signaling pathway in NPC， and reviews the research status regarding the anti-NPC effect of active components of traditional Chinese medicine （TCM） and TCM compound prescriptions by regulating this signaling pathway. The results show that TCM active components， including flavonoids （luteolin， maackiain， baicalein， etc.）， alkaloids （picrasidine Ⅰ， tetrandrine， etc.）， terpenoids （bakuchiol， cantharidic acid）， as well as traditional Chinese medicine compound formulas （such as Biyan jiedu capsules and Yiqi jiedu formula） can exert effects including inducing autophagy and apoptosis of NPC cells， promoting pyroptosis， reversing drug resistance， blocking epithelial-mesenchymal transition， weakening cell stemness and arresting cell cycle progression by regulating the MAPK signaling pathway， thereby inhibiting the occurrence and development of NPC through multiple pathways. |
| 期刊： | 2026年第37卷第01期 |
| 作者： | 李媛媛；曹洋；姜雨饮；张馨月；李静波 |
| AUTHORS： | LI Yuanyuan，CAO Yang，JIANG Yuyin，ZHANG Xinyue，LI Jingbo |
| 关键字： | 中药；丝裂原激活的蛋白激酶；信号通路；鼻咽癌；研究进展 |
| KEYWORDS： | traditional Chinese medicine； mitogen-activated protein kinase； signaling pathway； nasopharyngeal carcinoma； |
| 阅读数： | 51 次 |
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