目的：优化白芍提取工艺。方法：以芍药苷含量为评价指标，以提取溶剂、溶剂用量、提取时间、提取次数为考察因素，采

用混合均匀设计法结合二次多项式逐步回归方程制作曲面图，对白芍提取工艺进行优化并进行验证试验。结果：白芍的最优提取

工艺为以90％乙醇为提取溶剂，溶剂用量为12 倍，提取时间为150 min，提取2 次；3 次验证试验中芍药苷含量实测值为2.821 4％、

2.795 7％、2.841 9％（RSD＝0.82％，n＝3），接近预测值2.848 4％。结论：本法简便、准确，建立的工艺可用于白芍的提取。

OBJECTIVE：To optimize the extraction technology of Paeonia lactiflora. METHODS：The surface figure made by

mixed uniform design combined with the quadratic polynomial stepwise regression equation is adopted to optimize the extraction

technology of P. lactiflora by using the content of paeoniflorin as index，with extraction solvent，the amount of extraction solvent，

extraction time，extraction times as factors. RESULTS：The optimal extraction technology of P. lactiflora was as follows as 90％

ethanol，12-folds extraction solvent，extracting for 150 min，extracting for 2 times. The measured value of 3 validation tests were

2.848 4％，2.795 7％，2.841 9％（RSD＝0.82％，n＝3），which was close to the predicted value 2.848 4％. CONCLUSIONS：The

method is convenient and accurate，and can be used for the extraction of P. lactiflora.