目的：研究骨疏灵颗粒方中各药材配伍对淫羊藿苷含量的影响。方法：以组方中黄芪、牛膝、牡蛎的配伍为因素，配伍后

处方煎煮液中淫羊藿苷总含量为指标，采用正交试验法考察不同药材配伍对淫羊藿苷含量的影响；测定含淫羊藿和黄芪配伍的煎

液的pH及沉淀中的淫羊藿苷含量。结果：黄芪的配伍对方中淫羊藿苷含量的影响具有统计学意义（P＜0.05），牡蛎、牛膝配伍则

无影响（P＞0.05），黄芪、牡蛎、牛膝对淫羊藿苷含量的影响不存在两两交互作用；各配伍煎液pH无明显差异；所有淫羊藿与黄芪

的配伍均可产生沉淀，且沉淀中淫羊藿苷含量升高。结论：淫羊藿配伍黄芪煎煮后可形成沉淀，由此降低煎液中淫羊藿苷的含量，

此变化与煎液的pH无相关性。

OBJECTIVE：To study the effects of the compatibility of medicinal materials on the content of icariin in Gushuling

granules formula. METHODS：The effects of the compatibility of medicinal materials on the content of icariin was investigated by

orthogonal design with the compatibility of Astragalus membranaceus，Achyranthes bidentata and Concha ostreae as factors，using

the content of icariin in decoction as index. The pH of mixture of Epimedium brevicornu and A. membranaceus，and the content of

icariin in precipitation were determined. RESULTS：The effects of the compatibility of A. membranaceus on the content of icariin

had statistical significance（P＜0.05）；the compatibility of A. bidentata and C. ostreae had no statistical significance（P＞0.05）；

the interactions between two medicinal materials had not been found；the pH of the mixtures had no significant difference；the compatibility

of E. brevicornu and A. membranaceus produced precipitation，and the content of icariin in precipitation increased. CONCLUSIONS：

The compatibility of E. brevicornu and A. membranaceus can produce precipitation，so as to decrease the content of

icariin in decoction，which is not influenced by pH value of decoction.