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米力农治疗新生儿持续性肺动脉高压的临床观察
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| 篇名： | 米力农治疗新生儿持续性肺动脉高压的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察米力农治疗新生儿持续性肺动脉高压的临床疗效及安全性。方法：选取52例新生儿持续性肺动脉高压患儿，按随机数字表法分为对照组和观察组，各26例。对照组患儿给予机械通气和静脉应用前列腺素等常规治疗；观察组患儿在对照组基础上给予米力农注射液负荷剂量50 μg/kg，10 min内静脉注射，维持剂量0.75 μg/（kg·min）。两组患儿均治疗48 h。比较两组患儿临床疗效及治疗前后血氧饱和度（SpO2）、动脉血氧分压（PaO2）、氧合指数（OI）、肺动脉压（PAP）、肺动脉平均压（PAMP）、左心室输出量（SV），并观察不良反应发生情况。结果：观察组患儿临床总有效率为92.31％，显著高于对照组的80.77％，差异有统计学意义（P＜0.05）。治疗前，两组患儿SpO2、PaO2、OI、PAP、PAMP、SV水平比较，差异无统计学意义（P＞0.05）；治疗后，两组患儿上述指标均显著改善，且观察组SpO2、PaO2、OI及SV显著高于对照组，PAP、PAMP显著低于对照组，差异均有统计学意义（P＜0.05）。两组患儿均未见明显不良反应发生。结论：米力农治疗新生儿持续肺动脉高压疗效显著，能明显改善患儿持续动脉高压状态，提高血氧含量，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of milrinone in the treatment of persistent pulmonary hypertension of newborn. METHODS： 52 newborns with persistent pulmonary hypertension were divided into control group and observation group according to random number table， with 26 cases in each group. The control group were given mechanical ventilation and intravenous prostaglandin therapy. Observation group was treated with Milrinone injection at loading dose of 50 μg/kg， 10 min intravenous injection， maintenance dose of 0.75 μg/（kg·min）. Both groups received treatment for 48 h. Clinical efficacies of 2 groups were compared as well as SpO2， PaO2， OI， PAP， PAMP and SV before and after treatment. The occurrence of ADR was compared between 2 groups. RESULTS： Total effective rate of observation group was 92.31％， which was significantly higher than 80.77％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in SpO2， PaO2， OI， PAP， PAMP and SV levels between 2 groups （P＞0.05）. After treatment， above indexes of 2 groups were improved significantly； SpO2， PaO2， OI and SV levels of observation group were significantly higher than those of control group， while PAP and PAMP levels were significantly lower than those of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Milrinone shows significant therapeutic efficacy in the treatment of persistent pulmonary hypertension of newborn， and can significantly improve persistent pulmonary hypertension and increased oxygen content of blood with good safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 钱爱民，矫凤飞 |
| AUTHORS： | QIAN Aimin，JIAO Fengfei |
| 关键字： | 米力农；新生儿持续性肺动脉高压；血氧含量；肺动脉压 |
| KEYWORDS： | Milrinone； Persistent pulmonary hypertension of newborn； Oxygen content of blood； Pulmonary artery pressure |
| 阅读数： | 577 次 |
| 本月下载数： | 8 次 |
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