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消石利胆胶囊与熊去氧胆酸胶囊治疗慢性胆固醇性结石性胆囊炎的疗效比较
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| 篇名： | 消石利胆胶囊与熊去氧胆酸胶囊治疗慢性胆固醇性结石性胆囊炎的疗效比较 |
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| 摘要： | 目的：比较消石利胆胶囊与熊去氧胆酸胶囊治疗慢性胆固醇性结石性胆囊炎的临床疗效。方法：选取于我院就诊的慢性胆固醇性结石性胆囊炎患者120例，按照随机数字表法分为观察组和对照组，各60例。观察组患者给予消石利胆胶囊每次1.2 g，po，tid（餐后）；对照组患者给予熊去氧胆酸胶囊每次250 mg，po，qd（晚餐后）。两组患者疗程均为6个月。观察两组患者的溶石有效率及治疗前后腹痛评分[采用疼痛评级指数（PRI）、视觉模拟量表（VAS）评分和现有疼痛强度（PPI）评价]、胆囊壁厚度，并比较临床疗效及治疗过程中不良反应发生情况。结果：观察组患者脱落3例，对照组患者脱落1例。治疗前，两组患者的PRI、VAS评分、PPI、胆囊壁厚度比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者上述指标均明显降低，且观察组PRI、VAS评分和PPI均明显低于对照组，差异均有统计学意义（P＜0.05）。观察组患者的溶石总有效率（64.91％）明显低于对照组（79.67％），差异有统计学意义（P＜0.05）；观察组患者临床总有效率（57.89％）略高于对照组（54.24％），但差异无统计学意义（P＞0.05）。两组患者不良反应发生率比较，差异均无统计学意义（P＞0.05）。结论：消石利胆胶囊与熊去氧胆酸胶囊对慢性胆固醇性结石性胆囊炎的临床疗效相当，且安全性较高，可作为治疗慢性胆固醇性结石性胆囊炎的备选药物。 |
| ABSTRACT： | OBJECTIVE： To compare clinical efficacy of Xiaoshi lidan capsules and Ursodeoxycholic acid capsules in the treatment of chronic cholesterol gallstone cholecystitis. METHODS： 120 patients with chronic cholesterol gallstone cholecystitis in our hospital were selected and divided into observation group and control group according to random number table， with 60 cases in each group. Observation group was given Xiaoshi lidan capsules 1.2 g， po， tid （after the meal）； control group was given Ursodeoxycholic acid capsules 250 mg， po， qd （after dinner）. Both group received treatment for 6 months. Effective rate of litholysis were observed in 2 groups as well as abdominal pain score [PRI， VAS score， present pain intensity （PPI）]， the thickness of gallbladder wall before and after treatment. Clinical efficacy and the occurrence of ADR were compared between 2 groups during treatment. RESULTS： 3 patients withdrew from the observation group and 1 patient withdrew from the control group. Before treatment， there was no statistical significance in PRI， VAS score， PPI and the thickness of gallbladder wall between 2 groups （P＞0.05）. After treatment， above indexes of 2 groups were decreased significantly， while PRI， VAS score and PPI in observation group was significantly lower than in control group， with statistical significance （P＜0.05）. The effective rate of litholysis （64.91％） in observation group was significantly lower than in control group （79.67％）， with statistical significance （P＜0.05）. Total effective rate of observation group （57.89％） was slightly higher than that of control group （54.24％）， without statistical significance （P＞0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Xiaoshi lidan capsules are similar to Ursodeoxycholic acid capsules in clinical efficacy for chronic cholesterol gallstone cholecystitis with good safety， and can be used as optional drug except for chronic cholesterol gallstone cholecystitis. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 谢江，周明忠，蒙谦，柳晓丹，杨帆 |
| AUTHORS： | XIE Jiang，ZHOU Mingzhong，MENG Qian，LIU Xiaodan，YANG Fan |
| 关键字： | 消石利胆胶囊；熊去氧胆酸胶囊；慢性胆固醇性结石性胆囊炎；疗效 |
| KEYWORDS： | Xiaoshi lidan capsules； Ursodeoxycholic acid capsules； Chronic cholesterol gallstone cholecystitis； Therapeutic efficacy |
| 阅读数： | 750 次 |
| 本月下载数： | 1 次 |
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