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早期应用鼠神经生长因子对老年电烧伤患者创面愈合的影响
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| 篇名： | 早期应用鼠神经生长因子对老年电烧伤患者创面愈合的影响 |
| TITLE： | |
| 摘要： | 目的：探讨早期应用鼠神经生长因子对老年电烧伤患者创面愈合的影响。方法：将78例老年电烧伤患者按随机数字表法分为对照组和观察组，各39例。 对照组患者给予电烧伤一般治疗措施，观察组患者在对照组治疗基础上于24 h内给予注射用鼠神经生长因子30 μg溶于2 ml 0.9％氯化钠注射液中肌内注射，qd。两组疗程均为2周。比较两组患者的临床疗效，治疗前及治疗后3、5、7 d的视觉模拟量表（VAS）评分变化，治疗后3、5、7 d的皮瓣成活率与创面愈合率，创面瘢痕恢复情况、创面血液灌流值和创面完全愈合时间，以及不良反应发生情况。结果：观察组患者的总有效率（94.9％）显著高于对照组（66.7％），差异有统计学意义（P＜0.05）；治疗后3、5、7 d，观察组患者的VAS评分显著低于对照组同时段，皮瓣成活率与创面愈合率显著高于对照组同时段，差异均有统计学意义（P＜0.05）；治疗后，观察组患者的温哥华瘢痕量表（VSS）评分显著低于对照组，创面血液灌流值显著高于对照组，完全愈合时间显著短于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：老年电烧伤患者早期应用鼠神经生长因子，能够有效降低VAS和VSS评分，提高皮瓣成活率与创面愈合率，增加创面血液灌流值，缩短完全愈合时间，临床疗效与安全性较好。 |
| ABSTRACT： | OBJECTIVE： To explore the effects of early treatment with mouse nerve growth factor on the wound healing in aged patients with electric burn. METHODS： 78 elderly patients with electric burn were divided into control group and observation group by random number table method， with 39 cases in each group. Control group was given routine method for electric burn， and observation group was additionally given Mouse nerve growth factor for injection 30 μg dissolved in 2 ml 0.9％ Sodium chloride injection within 24 h， im， qd， on the basis of control group. Treatment course of 2 groups lasted for 2 weeks. Clinical efficacies of 2 groups were compared as well as VAS score before treatment， 3， 5， 7 days after treatment. The survival rate of skin flaps and the rate of wound healing 3， 5， 7 days after treatment， the recovery of wound scar， the value of wound blood perfusion， the time of complete wound healing and the occurrence of ADR were also compared. RESULTS： The total effective rate of observation group （94.9％） was significantly higher than that of control group （66.7％）， with statistical significance （P＜0.05）. 3， 5， 7 days after treatment， VAS score of observation group was significantly lower than that of control group， and the survival rate of skin flaps and the rate of wound healing were significantly higher than those of control group， with statistical significance （P＜0.05）. After treatment， VSS score of observation group was significantly lower than that of control group， while the value of wound blood perfusion was significantly higher than that of control group； the time of complete wound healing was significantly lower than that of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Early treatment with mouse nerve growth factor for elderly patients with electric burns can effectively lower the VAS and VSS score， improve the survival rate of skin flaps and the rate of wound healing， increase the value of wound blood perfusion and shorten the time of complete wound healing with good clinical efficacy and safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 杨蒙，吴宏志，邵洪波，冯建科，魏伟，孟令敏，张庆富 |
| AUTHORS： | YANG Meng，WU Hongzhi，SHAO Hongbo，FENG Jianke，WEI Wei，MENG Lingmin，ZHANG Qingfu |
| 关键字： | 电烧伤；鼠神经生长因子；创面愈合；老年患者 |
| KEYWORDS： | Electric burn； Mouse nerve growth factor； Wound healing； Elderly patient |
| 阅读数： | 320 次 |
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