清咽利肺散剂的止咳、化痰、抗炎和止痛作用研究
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篇名: 清咽利肺散剂的止咳、化痰、抗炎和止痛作用研究
TITLE:
摘要: 目的:考察清咽利肺散剂的止咳、化痰、抗炎和止痛作用。方法:将小鼠分为模型组、阳性对照组(炎见宁片,0.29 g/kg)和清咽利肺散剂低、中、高剂量组(13.7、27.3、54.6 g/kg),每组10只。模型组小鼠ig等体积生理盐水,各给药组小鼠ig相应药物,每天1次,连续7 d。给药结束后,分别采用小鼠氨水引咳实验、气管酚红排泌实验、二甲苯致耳肿胀实验和醋酸扭体实验考察清咽利肺散剂的止咳、化痰、抗炎、止痛作用。结果:与模型组比较,除清咽利肺散剂低剂量组小鼠外,其余各组小鼠的咳嗽次数均明显减少,且清咽利肺散剂高剂量组小鼠的咳嗽潜伏期明显延长(P<0.05或P<0.01);阳性对照组和清咽利肺散剂高剂量组小鼠的酚红排泌量、20 min内扭体次数明显减少,耳肿胀度明显减轻(P<0.05或P<0.01)。结论:清咽利肺散剂对小鼠具有良好的止咳、化痰、抗炎、消肿止痛的作用。
ABSTRACT: OBJECTIVE: To investigate the effects of Qingyan lifei powder(QYLFP)on relieving cough, reducing phlegm, inhibiting inflammatory and relieving pain. METHODS: The mice were divided into model group, positive control group (Yanjianning tablet, 0.29 g/kg), QYLFP low-dose, medium-dose and high-dose groups (13.7, 27.3, 54.6 g/kg), with 10 mice in each group. Model group was given constant volume of normal saline intragastrically, and treatment groups were given relevant medicine intragastrically, once a day, for 7 days. After medication, the effects of relieving cough, reducing phlegm, anti-inflammatory and analgesic of QYLFP were investigated through ammonia-induced cough method, phenol red method, xylene-caused mice ear edema test and acetic acid writhing test. RESULTS: Compared with model group, the cough times of those groups decreased significantly, except for QYLFP low-dose group; the cough incubation period in QYLFP high-dose group prolonged significantly (P<0.05 or P<0.01). The phenol red excretion amount and writhing times within 20 min of mice decreased significantly and ear edema relieved significantly in positive control and QYLFP high-dose group (P<0.05 or P<0.01). CONCLUSIONS: QYLFP has good effects on relieving acough, reducing sputum and inhibiting inflammatory and relieving pain.
期刊: 2016年第27卷第31期
作者: 张丽,张一云,符洪,王开裕,雷玲芳,王春桃
AUTHORS: ZHANG Li,ZHANG Yiyun,FU Hong,WANG Kaiyu,LEI Lingfang,WANG Chuntao
关键字: 清咽利肺散剂;止咳;化痰;消炎;止痛;小鼠
KEYWORDS: Qingyan lifei powder; Relieving cough; Reducing phlegm; Inhibiting inflammatory; Relieving pain; Mice
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