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阿奇霉素联合小儿消积止咳口服液治疗小儿支原体肺炎的疗效分析
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| 篇名： | 阿奇霉素联合小儿消积止咳口服液治疗小儿支原体肺炎的疗效分析 |
| TITLE： | |
| 摘要： | 目的：探讨阿奇霉素联合小儿消积止咳口服液治疗小儿支原体肺炎的临床疗效和安全性。方法：回顾性分析120例小儿支原体肺炎患儿的资料，按照治疗方式的不同分为观察组（63例）和对照组（57例）。两组患儿入院后均进行常规退热、止咳、化痰治疗。在此基础上，对照组患儿给予阿奇霉素10 mg/kg，静脉滴注，每日1次，连续输注3 d后停药4 d。观察组患儿在对照组治疗基础上加服小儿消积止咳口服液，5岁以下患儿每次服用10 ml，5岁及5岁以上患儿每次服用15 ml，每日3次。1周为1个疗程，两组均连续治疗2～3个疗程。观察两组患儿临床疗效，比较两组患儿临床体征消失时间和治疗前及治疗1周后嗜酸性粒细胞数量和血清C反应蛋白（CRP）水平，同时记录治疗过程中不良反应发生情况。结果：治疗后观察组患儿总有效率显著高于对照组，退热时间、咳嗽消失时间、肺部啰音消失时间、X线片肺部病灶消失时间显著短于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患儿嗜酸性粒细胞数量和血清CRP水平比较差异均无统计学意义（P＞0.05）。治疗1周后，两组患儿嗜酸性粒细胞数量和血清CRP水平显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。两组患儿总不良反应发生率比较差异无统计学意义（P＞0.05）。结论：阿奇霉素联合小儿消积止咳口服液治疗小儿支原体肺炎疗效较好，可以缩短患儿临床症状消失时间，改善炎症细胞水平，且不增加不良反应的发生。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of Azithromycin combined with Xiaoer xiaoji zhike oral solution in the treatment of mycoplasma pneumonia in children. METHODS： Data of 120 children with mycoplasma pneumonia were retrospectively analyzed and divided into observation group （63 cases） and control group （57 cases） by different treatment methods. All children received conventional treatment（reducing fever，relieving cough and resolving phlegm）. Based on it，control group received Azithromycin 10 mg/kg， intravenous infusion， once a day， after continuous infusion of 3 d， it stopped 4 d. Observation group additionally received Xiaoer xiaoji zhike oral solution， 10 ml for children younger than 5 years old， 15 ml for children in 5 years old or over， 3 times a day. 1-week was regarded as 1 treatment course， and it lasted for 2-3 courses. Clinical efficacy in 2 group was observed， recovery time of clinical signs， reduction of the number of inflammatory cells before and after treatment were compared， and the incidence of adverse reactions during treatment was recorded. RESULTS： After treatment， the total effective rate in observation group was significantly higher than control group， fever clearance time， disappearance time of cough， rales and pulmonary lesions were significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no significant difference in the number of eosinophils and serum C reactive protein （CRP） level （P＞0.05）. After 1 week treatment， the number of eosinophils and CRP level in 2 groups were significantly lower than before， and observation group was significantly lower than control group， with statistical significance （P＜0.05）. And there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS： Azithromycin combined with Xiaoer xiaoji zhike oral solution shows good efficacy in the treatment of mycoplasma pneumonia in children， it can shorten the duration of clinical symptoms， improve the level of inflammatory cells， and does not increase the incidence of adverse reactions. |
| 期刊： | 2016年第27卷第30期 |
| 作者： | 马雪萍，刘利英 |
| AUTHORS： | MA Xueping，LIU Liying |
| 关键字： | 阿奇霉素；小儿消积止咳口服液；支原体肺炎；疗效 |
| KEYWORDS： | Azithromycin； Xiaoer xiaoji zhike oral liquid； Mycoplasma pneumonia； Efficacy |
| 阅读数： | 1015 次 |
| 本月下载数： | 3 次 |
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