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金匮肾气丸对比生精胶囊治疗行为干预下少弱精子症的临床观察
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| 篇名： | 金匮肾气丸对比生精胶囊治疗行为干预下少弱精子症的临床观察 |
| TITLE： | |
| 摘要： | 目的：比较金匮肾气丸与生精胶囊治疗行为干预下少弱精子症的疗效和安全性。方法： 98例少弱精子症患者随机分为生精胶囊组（49例）和金匮肾气丸组（49例）。两组患者均给予行为干预治疗（认知干预、心理干预、饮食干预和运动干预等）。在此基础上，生精胶囊组患者给予生精胶囊1.6 g，口服，每日3次；金匮肾气丸组患者给予金匮肾气丸6 g，口服，每日2次。两组疗程均为3个月。观察两组患者的临床疗效，治疗前后的精液质量（精液量、精子密度、精子活动率、精子活力）、性激素[睾酮（T）、卵泡刺激素（FSH）、促黄体生成素（HLH）、孕酮（P）、催乳素（PRL）]水平及不良反应发生情况。结果：生精胶囊组患者总有效率显著高于金匮肾气丸组，差异有统计学意义（P＜0.05）。治疗前，两组患者精液质量、性激素水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者精液质量均显著高于同组治疗前，且生精胶囊组患者精液量、精子活力高于金匮肾气丸组，差异均有统计学意义（P＜0.05）；两组患者T水平均显著高于同组治疗前，但生精胶囊组低于金匮肾气丸组，差异均有统计学意义（P＜0.05）；两组治疗前后FSH、HLH、P、PRL比较差异均无统计学意义（P＞0.05）。两组患者不良反应发生率比较差异无统计学意义（P＞0.05）。结论：行为干预下，生精胶囊治疗少弱精子症的疗效优于金匮肾气丸，可显著改善精液质量，但在改善性激素水平方面不如金匮肾气丸；两药的安全性均较好。 |
| ABSTRACT： | OBJECTIVE： To compare the efficacy and safety of Jinkui shenqi pill versus Shengjing capsule in the treatment of oligoasthenozoosperimia under behavioral intervention. METHODS： 98 patients with oligoasthenozoosperimia were randomly divided into Shengjing capsule group （49 cases） and Jinkui shenqi pill （49 cases）. All patients received intervention treatment （cognitive intervention， psychological intervention， diet intervention and exercise intervention， etc.）. Based on it， Shengjing capsule group received 1.6 g Shengjing capsules， orally， 3 times a day； Jinkui shenqi pill group received 6 g Jinkui shenqi pill， orally， twice a day. They were treated for 3 months. Clinical efficacy， semen quality （semen volume， sperm concentration， sperm motility rate， sperm motility） and sex hormone levels [testosterone （T）， follicle stimulating hormone （FSH）， luteinizing hormone （HLH）， progesterone （P）， prolactin （PRL）] before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in Shengjing capsule group was significantly higher than Jinkui shenqi pill group， with statistical significance （P＜0.05）. Before treatment， there were no significant differences in semen quality and sex hormone levels （P＞0.05）. After treatment， semen quality in 2 groups was significantly higher than before， semen volume and sperm motility in Shengjing capsule group were higher than Jinkui shenqi pill group， with statistical significances （P＜0.05）. T levels in 2 groups were significantly higher than before， while Shengjing capsule group was lower than Jinkui shenqi pill group， with statistical significances （P＜0.05）； and there were no significant differences in FSH， HLH， P and PRL before and after treatment in 2 groups （P＞0.05）. And there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS： Under behavioral intervention， Shengjing capsule has better efficacy than Jinkui shenqi pill in the treatment of oligoasthenozoosperimia， it can significantly improve semen quality， while Jinkui shenqi pill is better in terms of improving sex hormone levels； and both show good safety. |
| 期刊： | 2016年第27卷第30期 |
| 作者： | 黄丽辉，黄日荷，邓丽萍，刘敏，冯旭升 |
| AUTHORS： | HUANG Lihui，HUANG Rihe，DENG Liping，LIU Min，FENG Xusheng |
| 关键字： | 少弱精子症；金匮肾气丸；生精胶囊；行为干预；精液质量；疗效；安全性 |
| KEYWORDS： | Oligoasthenozoosperimia； Jinkui shenqi pill； Shengjing capsule； Behavioral intervention； Sperm quality； Efficacy； Safety |
| 阅读数： | 758 次 |
| 本月下载数： | 1 次 |
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