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子宫动脉栓塞术联合甲氨蝶呤、乳酸依沙吖啶对妊娠中期前置胎盘引产妇女相关指标的影响
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| 篇名： | 子宫动脉栓塞术联合甲氨蝶呤、乳酸依沙吖啶对妊娠中期前置胎盘引产妇女相关指标的影响 |
| TITLE： | |
| 摘要： | 目的：探讨子宫动脉栓塞术联合甲氨蝶呤、乳酸依沙吖啶对妊娠中期前置胎盘引产妇女相关指标的影响。方法：回顾性分析100例妊娠中期前置胎盘需要引产妇女资料，按治疗方法的不同分为观察组（50例）和对照组（50例）。对照组妊娠期妇女引产前行双侧子宫动脉栓塞术，12 h后给予乳酸依沙吖啶注射液100 mg，羊膜腔注射+口服米非司酮片75 mg，用药2 d后引产。观察组妊娠期妇女双侧子宫动脉灌注后，行双侧子宫动脉栓塞术，当子宫动脉栓塞导管进入子宫动脉后给予注射用甲氨蝶呤50 mg/侧， 12 h后给予乳酸依沙吖啶注射液（用法用量同对照组）+口服米非司酮片（用法用量同对照组）。观察两组妊娠期妇女总产程、产时出血量、住院时间、月经复潮时间，剖宫取胎、子宫切除、胎盘残留及清宫情况，记录术后并发症。结果：观察组妊娠期妇女产时出血量、住院时间、剖宫取胎率、子宫切除率均显著低于对照组，差异均有统计学意义（P＜0.05），但两组总产程、月经复潮时间、胎盘残留率、清宫率比较，差异均无统计学意义（P＞0.05）。两组妊娠期妇女术后并发症发生率比较差异无统计学意义（P＞0.05）。结论：子宫动脉栓塞术联合甲氨蝶呤、乳酸依沙吖啶能有效降低妊娠中期前置胎盘引产妇女的出血量，缩短住院时间，降低剖宫取胎率及子宫切除率。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of uterine arterial embolization combined with Methotrexate and Lactate ethacridine on related indexes of mid-pregnant patients with placenta previa abortion. METHODS：The data of 100 mid-pregnant patients with placenta previa who required inducing labor was retrospectively analyzed and divided into observation group （50 cases） and control group （50 cases） by different treatment. Control group received uterine arterial embolization before inducing labor， then received Lactate ethacridine injection 100 mg， amniotic injection + Mifepristone tablet 75 mg， and aborted after 2 d. Observation group received uterine arterial embolization after uterine arterial perfusionon both sides， then received Methotrexate for injection 50 mg/side after uterine arterial embolization catheter entering uterine artery， Lactate ethacridine injection （the same usage and dosage as control group）+Mifepristone tablet （the same usage and dosage as control group） was given after 12 h. Total parturition， intrapartum hemorrhage， hospitalization time， menstruation recovery time， cesarean section， hysterectomy， retained placenta and clearing palace in 2 groups were observed， and postoperative complications were recorded. RESULTS： Intrapartum hemorrhage， hospitalization time， cesarean section rate and hysterectomy rate in observation group were significantly lower than control group， with statistical significance （P＜0.05）， while there were no significant differences in total parturition， menstruation recovery time， retained placenta rate and clearing palace rate in 2 groups （P＞0.05）. There was no significant difference in the incidence of postoperative complications in 2 groups （P＞0.05）. CONCLUSIONS： Uterine arterial embolization combined with Methotrexate and Lactate ethacridine can effectively reduce the hemorrhage of mid-pregnant patients with placenta previa abortion， shorten hospitalization time， and decrease cesarean section and hysterectomy rate. |
| 期刊： | 2016年第27卷第30期 |
| 作者： | 高素娟，刘彬，陈媛媛，付立平，张娜 |
| AUTHORS： | GAO Sujuan，LIU Bin，CHEN Yuanyuan，FU Liping，ZHANG Na |
| 关键字： | 子宫动脉栓塞术；甲氨蝶呤；乳酸依沙吖啶；米非司酮；前置胎盘；引产 |
| KEYWORDS： | Uterine arterial embolization； Methotrexate； Lactate ethacridine； Mifepristone； Placenta previa； Induced labor |
| 阅读数： | 448 次 |
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