注射用尖吻蝮蛇血凝酶致过敏性休克的药学监护-中国药房

注射用尖吻蝮蛇血凝酶致过敏性休克的药学监护

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篇名：	注射用尖吻蝮蛇血凝酶致过敏性休克的药学监护
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摘要：	目的：指导注射用尖吻蝮蛇血凝酶的临床合理使用，为其药学监护提供依据。方法：统计2009－2015年中国知网和维普数据库中收录的9例关于注射用尖吻蝮蛇血凝酶所致的过敏性休克病例的处理方法及转归，结合1例遵义医学院附属医院静脉注射注射用尖吻蝮蛇血凝酶引起过敏性休克的病例，进行分析。结果：10例注射用尖吻蝮蛇血凝酶所致过敏性休克患者主要用药目的是手术前后以及月经流血过多等方面的止血；用药剂量为1 U和2 U，以iv，ivgtt方式给药；过敏性休克发生的时间都在30 min内。结论：部分患者使用注射用尖吻蝮蛇血凝酶为超说明书用药，给药方式也未遵照说明书；该药所致过敏性休克病情发生迅猛，应在严格按照说明书和权威文献的基础上用正规用药，且用药前需做好应急预案，确保用药安全。
ABSTRACT：	OBJECTIVE： To guide rational use of Heamocoagulase agkistrodon for injection， and to provide reference for pharmaceutical care. METHODS： Treatment methods and outcome of 9 cases of allergic shock induced by Heamocoagulase agkistrodon for injection were retrieved from CNKI and VIP database during 2009-2015， and then analyzed statistically， based on one case of allergic shock induced by Heamocoagulase agkistrodon for injection in the Affiliated Hospital of Zhunyi Medical College. RESULTS： 10 pationts with allergic shock induced by Heamocoagulase agkistrodon for injection mainly used the drug for hemostasis before and after surgery， heavy menstrual bleeding， etc.， with dose of 1 or 2 U. Route of administration included intravenous injection and intravenous dripping. Allergic shock often occurred within 30 min after medication. CONCLUSIONS： The use of Heamocoagulase agkistrodon for injection in some patients belongs to off-label drug use， and route of administration is different from that stated in package inserts. Allergic shock induced by Heamocoagulase agkistrodon for injection occurs rapidly； the drug should be used strictly according to package inserts and authoritative literatures； emergency plan should be developed before medication in order to guarantee the safety of drug use.
期刊：	2016年第27卷第29期
作者：	王立云，龚磊，赵吉兰
AUTHORS：	WANG Liyun，GONG Lei，ZHAO Jilan
关键字：	注射用尖吻蝮蛇血凝酶；过敏性休克；药学监护
KEYWORDS：	Heamocoagulase agkistrodon for injection； Allergic shock； Pharmaceutical care
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