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瑞舒伐他汀对血脂异常的老年患者血脂及甲状腺结节的影响
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| 篇名： | 瑞舒伐他汀对血脂异常的老年患者血脂及甲状腺结节的影响 |
| TITLE： | |
| 摘要： | 目的：探讨瑞舒伐他汀对血脂异常的老年患者血脂及甲状腺结节的影响及安全性。方法：选择血脂异常的老年患者70例，按随机数字表法分为对照组（33例）和治疗组（37例）。对照组患者严格戒烟、戒酒和摄入低脂饮食，每晚睡前口服阿司匹林肠溶片100 mg等常规治疗；治疗组患者在对照组基础上每晚睡前口服瑞舒伐他汀钙片10 mg。两组患者均连续治疗12周。比较两组患者治疗前后体质量指数（BMI）、血脂水平及甲状腺结节大小，并观察不良反应发生情况。结果：两组患者治疗前后BMI比较，差异无统计学意义（P＞0.05）。治疗前，两组患者血脂水平及甲状腺结节大小比较，差异无统计学意义（P＞0.05）；治疗后，两组患者血脂水平及甲状腺结节大小显著改善，且治疗组明显优于对照组，差异均有统计学意义（P＜0.05）。治疗组2例患者出现丙氨酸转氨酶升高，未予特殊处理恢复正常。结论：瑞舒伐他汀能明显改善血脂异常的老年患者血脂水平，减小甲状腺结节，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects and safety of rosuvastatin on blood lipid and thyroid nodules in elderly patients with dyslipidemia. METHODS： 70 elderly patients with dyslipidemia were selected and randomly divided into control group （33 cases） and treatment group （37 cases）. Control group was treated with routine treatment as abstain from tobacco and drink， low fat diet， Aspirin enteric-coated tablets 100 mg at bed time； treatment group was additionally treated with Rosuvastatin calcium tablet 10 mg at bed time， on the basis of control group. Both groups received the treatment for consecutive 12 weeks. BMI， blood lipid and the size of thyroid nodules were compared between 2 groups before and after treatment， and the occurrence of ADR was also observed. RESULTS： There was no significant difference in BMI between 2 groups before and after treatment （P＞0.05）. There was no significant difference in blood lipid level and the size of thyroid nodules between 2 groups before and after treatment （P＞0.05）. The blood lipid level and the size of thyroid nodule of 2 groups were improved significantly after treatment， and the treatment group was significantly better than the control group， with statistical significance （P＜0.05）. 2 pationts of creatment suffered from the increase of ALT but recovered withont angtreatment. CONCLUSIONS： Rosuvastatin can significantly improve blood lipid and decrease thyroid nodules in elderly patients with dyslipidemia with good safety. |
| 期刊： | 2016年第27卷第29期 |
| 作者： | 王艳飞，焦丽，赵红玲，薛燕，李文秀 |
| AUTHORS： | WANG Yanfei，JIAO Li，ZHAO Hongling，XUE Yan，LI Wenxiu |
| 关键字： | 瑞舒伐他汀；老年患者；血脂异常；甲状腺结节 |
| KEYWORDS： | Rosuvastatin； Elderly patients； Dyslipidemia； Thyroid nodules |
| 阅读数： | 908 次 |
| 本月下载数： | 5 次 |
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