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维A酸联合常规三联药物治疗口腔白斑的临床观察
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| 篇名： | 维A酸联合常规三联药物治疗口腔白斑的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察维A酸联合维生素A、维生素E、塞来昔布治疗口腔白斑的疗效和安全性。方法：104例口腔白斑患者随机分为对照组（52例）和观察组（52例）。对照组患者口服维生素A胶丸 1粒，每日3次+维生素 E胶丸 1粒，每日3次+塞来昔布胶囊1粒，每日2次。观察组患者在对照组治疗的基础上口服维A酸片1片，每日2次。两组均以4周为1个疗程，共治疗3个疗程。观察两组患者的临床疗效，治疗前后白斑数目、白斑最大直径、免疫球蛋白A（IgA）、IgM、IgG水平及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗前，两组患者白斑数目、白斑最大直径、免疫球蛋白水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者白斑数目、白斑最大直径和IgA、IgM水平均显著低于同组治疗前，且观察组低于对照组，IgG水平显著高于同组治疗前，且观察组高于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较差异无统计学意义（P＞0.05）。结论：维A酸联合维生素A、维生素E、塞来昔布治疗口腔白斑的疗效显著，可有效缓解临床症状，改善机体免疫功能，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of vitamin A acid combined with vitamin A， vitamin E， celecoxib in the treatment of oral leukoplakia. METHODS： 104 patients with oral leukoplakia were randomly divided into control group （52 cases） and observation group （52 cases）. Control group received 1 Vitamin A soft capsule， 3 times a day+1 Vitamin E soft capsule， 3 times a day+1 Celecoxib capsule， twice a day. Observation group additionally received 1 Vitamin A acid tablet， twice a day. 4-week was regarded as 1 treatment course， it lasted for 3 courses. Clinical efficacy， and leukoplakia number， maximum diameter of leukoplakia， immunoglobulin A （IgA）， IgM， IgG before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant （P＜0.05）. Before treatment， there were no significant differences in leukoplakia number， maximum diameter of leukoplakia， immunoglobulin levels in 2 groups （P＞0.05）. After treatment， leukoplakia number， maximum diameter of leukoplakia，IgA and IgM in 2 groups were significantly lower than before， and observation group was lower than control group， IgG was significantly higher than before， and observation group was higher than control group， the differences were statistically significant （P＜0.05）. And there was no significant difference in the incidence of adverse reactions in 2 groups （P＞0.05）. CONCLUSIONS： Vitamin A acid combined with vitamin A，vitamin E， celecoxib shows obvious efficacy in the treatment of oral leukoplakia， it can effectively reduce clinical symptoms， improve immune function， with good safety. |
| 期刊： | 2016年第27卷第27期 |
| 作者： | 宋惠珠，於俊 |
| AUTHORS： | SONG Huizhu，YU Jun |
| 关键字： | 口腔白斑；维A酸；维生素A；维生素E；塞来昔布；疗效；安全性 |
| KEYWORDS： | Oral leukoplakia； Vitamin A acid； Vitamin A； Vitamin E； Celecoxib； Efficacy； Safety |
| 阅读数： | 709 次 |
| 本月下载数： | 3 次 |
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