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氯吡格雷联合阿司匹林治疗老年短暂性脑缺血发作的临床观察
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| 篇名： | 氯吡格雷联合阿司匹林治疗老年短暂性脑缺血发作的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察氯吡格雷联合阿司匹林治疗老年短暂性脑缺血发作的疗效和安全性。方法： 90例短暂性脑缺血发作老年患者随机分为观察组（50例）和对照组（40例）。两组患者均予以缺血性脑卒中患者常规治疗，包括他汀类药物、低分子右旋糖酐、尿激酶等药物，对于合并其他基础疾病者给予对症治疗。在此基础上，对照组患者口服阿司匹林肠溶片100 mg，每日1次；观察组患者在对照组治疗的基础上口服硫酸氢氯吡格雷片75 mg，每日1次。两组均需避免服用其他种类抗血小板药。两组均连续治疗6个月。观察两组患者的临床疗效，治疗前后血小板功能指标（CD63、CD62p），随访治疗6个月后的复发率及脑卒中发生率，记录不良反应发生情况。结果：观察组患者总有效率显著高于对照组，复发率及脑卒中发生率均显著低于对照组，差异均有统计学意义（P＜0.05）。治疗后，两组患者CD63、CD62p水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗期间均未见明显不良反应发生。结论：在常规治疗的基础上，氯吡格雷联合阿司匹林治疗老年短暂性脑缺血发作的疗效优于单用阿司匹林，可降低其复发率和脑卒中发生率，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of clopidogrel combined with aspirin in the treatment of transient ischemic attack in the elderly. METHODS： 90 elderly patients with transient ischemic were randomly divided into observation group （50 cases） and control group （40 cases）. All patients received conventional treatment， statins， low molecular weight dextran and urokinase， etc.， symptomatic treatment was conducted for patients combined with other underlying diseases. Based on it， control group received 100 mg Aspirin enteric-coated tablet， once a day； observation group additionally received 75 mg Clopidogrel bisulfate tablet， once a day. No other antiplatelet drugs were allowed. They treatment for 6 months. Clinical efficacy， platelet function indexes （CD63， CD62p） before and after treatment， recurrence rate and incidence of cerebral stroke after 6 months follow-up in 2 groups were observed， and the incidence of adverse reactions was recorded. RESULTS： The total effective rate in observation group was significantly higher than control group， recurrence rate and incidence of cerebral stroke were significantly lower than control group， the differences were statistically significant （P＜0.05）. After treatment， CD63 and CD62p levels in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant （P＜0.05）. And there were no obvious adverse reactions during treatment. CONCLUSIONS： Based on conventional treatment， clopidogrel combined with aspirin shows better efficacy than aspirin alone in the treatment of transient ischemic attack in the elderly， it can reduce the incidence of cerebral stroke and recurrence rate， with good safety. |
| 期刊： | 2016年第27卷第27期 |
| 作者： | 史冬，杜志顺 |
| AUTHORS： | SHI Dong，DU Zhishun |
| 关键字： | 氯吡格雷；阿司匹林；短暂性脑缺血；疗效；安全性 |
| KEYWORDS： | Clopidogrel； Aspirin； Transient cerebral ischemia； Efficacy； Safety |
| 阅读数： | 230 次 |
| 本月下载数： | 4 次 |
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