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快速康复外科辅助FOLFOX化疗方案对结直肠癌患者术后恢复、并发症及生存质量的影响
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| 篇名： | 快速康复外科辅助FOLFOX化疗方案对结直肠癌患者术后恢复、并发症及生存质量的影响 |
| TITLE： | |
| 摘要： | 目的：探讨快速康复外科辅助氟尿嘧啶、奥沙利铂、亚叶酸钙（FOLFOX）化疗方案对结直肠癌患者术后恢复、并发症及生存质量的影响。方法：60例结直肠癌患者随机分为对照组（30例）和观察组（30例）。行结直肠癌切除术后，对照组患者给予注射用奥沙利铂85 mg/m2，静脉滴注2 h，d1+注射用左亚叶酸钙200 mg/m2，静脉注射，qd，d1-2+氟尿嘧啶注射液400 mg/m2，静脉注射，qd，d1-5，后给予600 mg/m2持续静脉滴注22 h，d1-2。观察组患者在对照组治疗的基础上行快速康复外科辅助。两组均以2周为1个周期，共治疗12个周期。观察两组患者尿潴留时间、肛门排气时间、首次排便时间、术后住院时间、生存质量评分（总体健康、生理功能、生理职能、躯体疼痛、活力、社会功能、情感功能、精神健康）并记录术后并发症发生情况。结果：观察组患者尿潴留时间、肛门排气时间、首次排便时间、术后住院时间均显著短于对照组，术后并发症总发生率显著低于对照组，总体健康、情感功能、精神健康评分均显著高于对照组，差异均有统计学意义（P＜0.05），但两组患者生理功能、生理职能、躯体疼痛、活力、社会功能评分比较，差异均无统计学意义（P＞0.05）。结论： 快速康复外科辅助FOLFOX化疗方案能降低结直肠癌患者术后并发症发生率，改善生存质量，缩短住院时间，促进术后恢复。 |
| ABSTRACT： | OBJECTIVE： To investigate the effect of rapid rehabilitation surgery assisted to fluorouracil， oxaliplatin， leucovorin （FOLFOX） on postoperative recovery， complications and quality of life in patients with colorectal cancer. METHODS： 60 patients with colorectal cancer were randomly divided into control group （30 cases） and observation group （30 cases）. After resection of colorectal cancer， control group received 85 mg/m2 Oxaliplatin for injection， 2 h intravenous infusion， d1+200 mg/m2 Calcium levofolinate for injection， intravenous infusion， once a day， d1-2+400 mg/m2 Fluorouracil injection， intravenous infusion， once a day，d1-5 then 600 mg/m2 for 22 h intravenous infusion， d1-2. Observation was additionally given rapid rehabilitation surgery. 2-week was regarded as 1 course， it lasted 12 courses. Urinary retention time， anal exhaust time， first defecation time， postoperative hospitalization time， scores of life quality （overall health，emotional function，mental health，physiological functions，physical function，somatic pain，vitality，social function） in 2 groups were observed， and the incidence of postoperative complications was recorded. RESULTS： The urinary retention time， anal exhaust time， first defecation time， postoperative hospitalization time in observation group were significantly shorter than control group， the incidence of postoperative complications in observation group was significantly lower than control group， overall health， emotional function and mental health score were significantly higher than control group， the differences were statistically significant （P＜0.05）， but there were no significant differences in physiological functions， physical function， somatic pain， vitality， social function score in 2 groups （P＞0.05）. CONCLUSIONS： Rapid rehabilitation surgery assisted to FOLFOX chemotherapy can reduce the incidence of postoperative complications in patients with colorectal cancer， improve quality of life， shorten hospitalization time and promote postoperative recovery. |
| 期刊： | 2016年第27卷第27期 |
| 作者： | 陆蓉，李俊蕾，贾平，陈蓉 |
| AUTHORS： | LU Rong，LI Junlei，JIA Ping，CHEN Rong |
| 关键字： | 快速康复外科；氟尿嘧啶；奥沙利铂；亚叶酸钙；结直肠癌；生存质量； 并发症；术后恢复 |
| KEYWORDS： | Rapid rehabilitation surgery； Fluorouracil； Oxaliplatin； Leucovorin； Colorectal cancer； Quality of life； Complication； Postoperative recovery |
| 阅读数： | 505 次 |
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