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舒肝颗粒辅助治疗黄褐斑伴月经不调的临床观察
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| 篇名： | 舒肝颗粒辅助治疗黄褐斑伴月经不调的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨舒肝颗粒辅助治疗女性黄褐斑伴月经不调的临床疗效及安全性。方法：将140例黄褐斑伴月经不调患者按随机数字表法分为观察组和对照组，各70例。对照组患者采用维生素C、维生素E及复方维甲酸等常规治疗；观察组患者在对照组基础上加用舒肝颗粒10 g，bid。21 d为1个疗程，两组患者均治疗2个疗程。观察两组患者治疗前后黄褐斑面积、月经不调评分，评价两组患者黄褐斑和月经不调的临床疗效，并记录不良反应发生情况。结果：治疗前，两组患者黄褐斑面积、月经不调积分比较，差异无统计学意义（P＞0.05）；治疗后，两组患者黄褐斑面积均显著缩小，且观察组明显小于对照组，月经不调积分显著降低，且观察组明显低于对照组，差异均有统计学意义（P＜0.05）。观察组患者黄褐斑和月经不调临床总有效率分别为61.86％和61.43％，显著高于对照组的45.71％和44.29％，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：舒肝颗粒辅助治疗黄褐斑伴月经不调患者疗效显著，能明显缩小黄褐斑面积及改善月经不调，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and safety of Shugan granule in the adjunctive treatment of melasma with irregular menstruation. METHODS： 140 cases of melasma with irregular menstruation were divided into observation group and control group according to random number table method， with 70 cases in each group. Control group was given vitamin C， vitamin E and compound retinoic acid and other routine medicines； observation group was additionally given Shugan granule 10 g，bid. A treatment course lasted for 21 d， and both groups received 2 courses of treatment. The area of melasma， irregular menstruation integral， clinical efficacy of melasma and irregular menstruation were observed in 2 groups， and the occurrence of ADR was recorded. RESULTS： There was no statistical significance in the area of melasma and irregular menstruation integral between 2 groups before treatment （P＞0.05）； after treatment， the area of melasma decreased significantly in 2 groups， and the observation group was significantly lower than the control group； irregular menstruation integral decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. Total effective rates of melasma and irregular menstruation were 61.86％ and 61.43％， which were significantly higher than those of control group （45.71％and 44.29％）， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Shugan granule shows significant therapeutic efficacy in adjunctive treatment of melasma with irregular menstruation， and can decrease the area of melasma and improve irregular menstruation significantly. |
| 期刊： | 2016年第27卷第26期 |
| 作者： | 李艳青，陈璐，杨琦，胡晓华 |
| AUTHORS： | LI Yanqing，CHEN Lu，YANG Qi，HU Xiaohua |
| 关键字： | 舒肝颗粒；黄褐斑；月经不调；疗效 |
| KEYWORDS： | Shugan granule； Melasma； Irregular menstruation； Effieaey |
| 阅读数： | 325 次 |
| 本月下载数： | 3 次 |
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