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银屑胶囊联合复方氟米松软膏治疗寻常型银屑病的临床观察
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| 篇名： | 银屑胶囊联合复方氟米松软膏治疗寻常型银屑病的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨银屑胶囊联合复方氟米松软膏治疗寻常型银屑病的临床效果及安全性。方法：将66例寻常型银屑病患者按随机数字表法分为对照组和观察组，各33例。 两组患者均局部外用复方氟米松软膏适量，bid；在此基础上，观察组患者加服银屑胶囊，每次1.35 g，tid。两组均治疗8周。比较两组患者治疗前后的银屑病皮损面积和严重程度指数（PASI）评分、皮肤病生活质量指数（DLQI）评分、血清炎症细胞因子水平，观察其临床疗效和不良反应发生情况。结果：治疗后，两组患者PASI评分与DLQI评分均较治疗前明显降低，且观察组患者明显低于对照组，差异均有统计学意义（P＜0.05）。观察组患者的有效率（84.85％）明显高于对照组（63.64％），差异有统计学意义（P＜0.05）。两组患者血清IL-8、TNF-α、VEGF水平均较治疗前明显降低，且观察组患者明显低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：银屑胶囊治疗寻常型银屑病可通过降低患者血清IL-8、TNF-α、VEGF等炎症细胞因子水平发挥确切的疗效，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and safety of Yinxie capsule combired with Compound flumethasone ointment in the treatment of psoriasis vulgaris. METHODS： 66 patients with psoriasis vulgaris were divided into control group and observation group accordirg to random number table methed， with 33 cases in each group. Both groups were treated with Compound flumethasone ointment for external use， bid； based on it， observation groups was additionally given Yinxie capsule， 1.35 g each time， tid. A treatment course lasted for 8 weeks. Psoriasis area and severity index（PASI） score， dermatosis life qulity index（DLQI） score and serum inflammatory cytokines level were compared in 2 groups before and after treatment， and clinical efficacy and the occurrence of ADR were observed. RESULTS： After treatment， PASI and DLQI scores of 2 groups were decreased significantly compared to before treatment； the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. The effective rate of observation group（84.85％） was significantly higher than that of control group（63.64％）， with statistical significance （P＜0.05）. After treatment， serum levels of IL-8， TNF-α and VEGF in 2 groups were significantly lowered compared to before treatment； the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups（P＞0.05）. CONCLUSIONS： Yinxie capsule shows definite clinical efficacy in the treatment of psoriasis vulgaris by lowering serum levels of IL-8， TNF-α，VEGF and other serum inflammatory cytokines with good safety. |
| 期刊： | 2016年第27卷第26期 |
| 作者： | 初金玉，刘丽英，鄂佳，杨静，王晶 |
| AUTHORS： | CHU Jinyu，LIU Liying，E Jia，YANG Jing，WANG Jing |
| 关键字： | 寻常型银屑病；银屑胶囊；复方氟米松软膏；炎症细胞因子；临床效果 |
| KEYWORDS： | Psoriasis vulgaris； Yinxie capsule； Compound flumethasone ointment； Inflammatory cytokines； Clinical efficacy |
| 阅读数： | 380 次 |
| 本月下载数： | 2 次 |
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