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补中益气五苓汤结合西医治疗慢性心力衰竭的临床观察
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| 篇名： | 补中益气五苓汤结合西医治疗慢性心力衰竭的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察补中益气五苓汤结合西医治疗慢性心力衰竭（CHF）的临床疗效及安全性。方法：将120例CHF患者按照随机数字表法分为观察组和对照组，各60例。对照组患者给予休息、低盐饮食、利尿药等西医基础治疗；观察组患者在对照组治疗基础上，加服补中益气五苓汤，每日1剂，以水煎后分2次服用。两组疗程均为2周。比较两组患者治疗前后的中医证候积分平均值、血浆N端脑钠肽（NT-proBNP）水平、6 min步行试验（6MWT）距离、临床疗效及不良反应发生情况。结果：治疗前，两组患者的中医证候积分平均值、血浆NT-proBNP水平、6MWT距离比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者的中医证候积分平均值和血浆NT-proBNP水平均较治疗前明显降低，且观察组患者明显低于对照组，差异均有统计学意义（P＜0.05）；两组患者的6MWT距离均较治疗前明显增加，且观察组明显长于对照组，差异均有统计学意义（P＜0.05）。治疗后，观察组患者的总有效率（93.33％）明显高于对照组（83.33％），差异有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：补中益气五苓汤是治疗CHF的有效组方，能缓解患者的临床症状、改善心功能、降低NT-proBNP水平、提高运动耐量，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of Buzhong yiqi wuling decoction combined with western medicine in the treatment of chronic congestive heart failure （CHF）. METHODS： 120 CHF patients were divided into observation group and control group by random number table method， with 60 cases in each group. Control group received conventional western medicine treatment as rest， low salt diet and diuretics. Observation group was additionally given Buzhong yiqi wuling decoction， one dose a day， at twice， on the basis of control group. Treatment course of 2 groups lasted for 2 weeks. Average TCM symptom score，level of plasma NT-proBNP， 6 min walk test（6MWT） distance before and after treatment， clinical efficacy and the occurrence of ADR were compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in average TCM symptom score， level of plasma NT-proBNP and 6MWT distance between 2 groups （P＞0.05）. After treatment， average TCM symptom score and level of plasma NT-proBNP of 2 groups were decreased significantly， and the observation group was more significant than the control group， with statistical significance （P＜0.05）； 6MWT distance of 2 groups were improved significantly compared to before treatment， and the observation group was significantly longer than the control group， with statistical significance （P＜0.05）. After treatment， total effective rate of observation group （93.33％） was significantly higher than that of control group （83.33％）， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Buzhong yiqi wuling decoction is an effective prescription to treat CHF， and can relieve clinical symptoms， improve the cardiac function， decrease NT-proBNP level and enhance the patient exercise tolerance with good safety. |
| 期刊： | 2016年第27卷第26期 |
| 作者： | 高伟铿，刘正旺，张明，彭志国，及孟，王转转，李光智，惠慧，卓书江 |
| AUTHORS： | GAO Weikeng，LIU Zhengwang，ZHANG Ming，PENG Zhiguo，JI Meng，WANG Zhuanzhuan，LI Guangzhi，HUI Hui，ZHUO Shujiang |
| 关键字： | 补中益气五苓汤；慢性心力衰竭；中医药；临床疗效 |
| KEYWORDS： | Buzhong yiqi wuling decoction； Chronic congestive heart failure； Traditional Chinese medicine； Clinical efficacy |
| 阅读数： | 245 次 |
| 本月下载数： | 3 次 |
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