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多药耐药基因多态性与利培酮及其代谢物血药浓度的相关性
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| 篇名： | 多药耐药基因多态性与利培酮及其代谢物血药浓度的相关性 |
| TITLE： | |
| 摘要： | 目的：探讨我国汉族精神分裂症患者多药耐药基因（MDR1）多态性与利培酮、9-羟基利培酮及总活性物血药浓度的相关性。方法：选择2011年10月－2013年1月中南大学湘雅二医院精神卫生研究所的汉族精神分裂症住院患者78例，采用高效液相色谱-串联质谱法测定其利培酮、9-羟基利培酮和总活性物的血药浓度，采用聚合酶链-连接酶检测反应法检测患者MDR1 C1236T、G2677T和C3435T的基因分型，采用单因素方差分析考察MDR1基因多态性与利培酮、9-羟基利培酮及总活性物血药浓度/剂量校正比（C/D）值的相关性。结果：78例患者体内利培酮、9-羟基利培酮及总活性物的平均血药浓度分别为（13.58±8.31）、（25.62±15.52）、（39.24±25.76）ng/ml；C1236T、G2677T和C3435T各基因型分布频率均符合Hardy-Weinberg平衡（P＞0.05）；C1236T CT和TT型患者利培酮的C/D值高于CC型患者，G2677T TT型患者利培酮与总活性物的C/D值均高于GG型患者，差异均有统计学意义（P＜0.05）；而其他基因型患者体内各待测物C/D值间的差异均无统计学意义（P＞0.05）。结论：汉族精神分裂症患者MDR1 C1236T和G2677T多态性与利培酮及总活性物的血药浓度相关。 |
| ABSTRACT： | OBJECTIVE： To discuss the correlation between multidrug resistance gene （MDR1） polymorphisms and plasma concentration of risperidone， 9-hydroxyrisperidone and total active substance in Han patients with schizophrenia. METHODS： 78 Han inpatients with schizophrenia in Mental Health Institute of Second Xiangya Hospital of Central South University from Dec. 2011 to Jan. 2013 were selected， LC-MS/MS was conducted to determine the plasma concentration of risperidone， 9-hydroxyrisperidone and total active substance， PCR-LDR was adopted to determine the genotyping of C1236T， G2677T and C3435T of patients， and one-way ANOVA was used to detect the correlation between C1236T， G2677T and C3435T polymorphisms and plasma concentration/dose calibration ratio （C/D） value of risperidone， 9-hydroxyrisperidone and total active substance. RESULTS： The average plasma concentrations of risperidone， 9-hydroxyrisperidone and total active substance for 78 patients were （13.58±8.31）， （25.62±15.52） and （39.24±25.76） ng/ml， respectively； the distribution frequencies of C1236T， G2677T and C3435T met the Hardy-Weinberg equilibrium （P＞0.05）； the risperidone C/D value of patients with C12367T CT and TT genotype were higher than those with CC genotype， risperidone and total active substance C/D values of patients with G2677T TT genotype were higher than those with GG genotype， the differences were statistically significant （P＜0.05）； while there were no significant differences in analyte C/D values in other patients （P＞0.05）. CONCLUSIONS： The MDR1 C1236T and G2677T polymorphisms are associated with plasma concentration of risperidone and total active substance in Han patients with schizophrenia. |
| 期刊： | 2016年第27卷第26期 |
| 作者： | 楼江，严伟，王刚，徐萍，李焕德，王飞 |
| AUTHORS： | LOU Jiang，YAN Wei，WANG Gang，XU Ping，LI Huande，WANG Fei |
| 关键字： | 多药耐药；基因多态性；利培酮；9-羟基利培酮；总活性物；血药浓度/剂量校正比；相关性 |
| KEYWORDS： | Multidrug resistance； Gene polymorphism； Risperidone； 9-hydroxyrisperidone； Total active substance； Plasma concentration/dose calibration ratio； Correlation |
| 阅读数： | 377 次 |
| 本月下载数： | 4 次 |
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