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野马追水煎液对自发性高血压大鼠的降压作用及其机制研究
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| 篇名： | 野马追水煎液对自发性高血压大鼠的降压作用及其机制研究 |
| TITLE： | |
| 摘要： | 目的：研究野马追水煎液对自发性高血压大鼠（SHR）的降压作用及其机制。方法：将50只SHR随机分为模型组、卡托普利片组（阳性药物，10 mg/g）和野马追水煎液高、中、低剂量组（65.45、32.73、16.36 g/kg），每组10只。模型组大鼠ig生理盐水，其余各组大鼠ig相应药物，每天1次，连续7周。每周测定大鼠尾动脉收缩压（SBP）和舒张压（DBP），记录大鼠在药物作用下血压的动态变化。7周后处死大鼠，测定血清中内皮素（ET）、血管紧张素（AngⅡ）和一氧化氮（NO）含量。结果：给药7周后，与模型组比较，各给药组大鼠尾动脉SBP、DBP均明显降低（P＜0.05），野马追水煎液降压效果呈现一定的量效和时效关系；各给药组大鼠血清中NO、AngⅡ含量明显减少，ET含量明显增加，且呈量效关系。结论：野马追水煎液对SHR有明显的降压作用，其机制可能与降低血清中NO、AngⅡ含量及升高血清中ET含量有关。 |
| ABSTRACT： | OBJECTIVE： To study the antihypertensive effects of water decoction of Eupatorium lindleyanum on spontaneously hypertensive rats （SHR） and corresponding mechanism. METHODS： 50 SHR were randomly divided into model group， captopril tablets group （positive drug， 10 mg/g） and the groups of high， medium and low-dose （65.45， 32.73， 16.36 g/kg） water decoction of E. lindleyanum， with 10 rats in each group. The rats in the model group were given normal saline ig， while those in other groups were given corresponding drugs ig， once a day， for 7 consecutive weeks. The systolic blood pressure （SBP） and diastolic blood pressure （DBP） of the caudal arteries of the rats were measured every week， and the dynamic changes in the blood pressure of the rats as a result of drug intervention were recorded. The rats were sacrificed 7 weeks later， and the levels of endothelin （ET）， angiotensin （AngⅡ） and nitric oxide （NO） in serum were determined. RESULTS： After 7 weeks of drug use， compared to the model group， the rats in the drug administration groups had significantly lower SBP and DBP of the caudal artery （P＜0.05）， showing obvious dose-effect and time-effect relationships in the antihypertensive effect of water decoction of E. lindleyanum， and had obviously lower levels of NO and AngⅡ and markedly higher level of ET in serum， demonstrating a dose-effect relationship. CONCLUSIONS： The water decoction of E. lindleyanum has an obvious antihypertensive effect by a mechanism which may be related to decrease in the levels of NO and AngⅡ in serum and increase in the level of ET therein. |
| 期刊： | 2016年第27卷第25期 |
| 作者： | 迟栋 |
| AUTHORS： | CHI Dong |
| 关键字： | 野马追水煎液；自发性高血压大鼠；降压 |
| KEYWORDS： | Water decoction of Eupatorium lindleyanum； Spontaneously hypertensive rats； Antihypertension |
| 阅读数： | 312 次 |
| 本月下载数： | 3 次 |
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