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心脉通片对动脉粥样硬化模型大鼠的防治作用及其机制研究
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| 篇名： | 心脉通片对动脉粥样硬化模型大鼠的防治作用及其机制研究 |
| TITLE： | |
| 摘要： | 目的：研究心脉通片对动脉粥样硬化（AS）模型大鼠的防治作用及其机制。方法：将48只大鼠随机分为正常组、模型组、阳性组（辛伐他汀片，2 mg/kg）和心脉通片高、中、低剂量组（500、250、125 mg/kg），每组8只。除正常组外，其余各组大鼠均给予高脂饲料+ip维生素D3复制AS模型；造模同时各给药组大鼠ig相应药物，正常组和模型组大鼠ig生理盐水，每天1次，连续10周。检测血清中胆固醇（TC）、三酰甘油（TG）、一氧化氮（NO）、内皮素1（ET-1）含量，光镜下观察主动脉组织的病理变化，并测定主动脉粥样斑块面积、内膜厚度。结果：与正常组比较，模型组大鼠血清中TC、TG、ET-1含量及主动脉粥样斑块面积、内膜厚度均显著增加，NO含量显著降低（P＜0.01）；主动脉有明显粥样硬化斑块形成。与模型组比较，除心脉通片低剂量组大鼠血清中TC降低不显著外，其余各给药组大鼠上述指标均明显改善（P＜0.05或P＜0.01），并与剂量呈正相关；各给药组大鼠主动脉病变均有改善。结论：心脉通片对AS模型大鼠有一定的防治作用，其机制可能与减少脂质沉积、减小动脉粥样斑块形成的面积、改善NO/ET平衡、减轻内皮损伤有关。 |
| ABSTRACT： | OBJECTIVE： To study the preventive and therapeutic effects of Xinmaitong tablets on model rats with atherosclerosis （AS） and corresponding mechanism. METHODS： 48 rats were randomized into normal group， model group， positive group （simvastatin tablets， 2 mg/kg） and the groups of high， medium and low-dose （500， 250， 125 mg/kg） Xingmaitong tablets， with 8 rats in each group. The rats in all groups except for the normal group were fed high fat diets and given vitamin D3 ip for the establishment of AS model. Meanwhile， the rats in the drug administration groups were given corresponding drugs ig， while those in the normal group and the model group were given normal saline ig， once a day， for 10 consecutive weeks. The levels of cholesterol （TC）， triacylglycerol （TG）， nitric oxide （NO） and endothelin 1 （ET-1） in serum were determined. The pathological change of the aorta tissue was observed under the light microscope， and the size of the aortic atherosclerotic plaque and intima thickness were measured. RESULTS： Compared to the normal group， the rats in the model group had significantly higher levels of TC， TG and ET-1 in serum， a markedly larger aortic atherosclerotic plaque， remarkably thicker intima and much lower level of NO （P＜0.01）； and obvious aortic atherosclerotic plaque formation was found. Compared to the model group， the above-mentioned indexes of the rats in all drug groups all improved obviously （P＜0.05 or P＜0.01）， except that the decrease in TC in serum of the rats in the group of low-dose Xinmaitong tablets was not significant， which were positively correlated with dose； and the aortic lesion in drug groups was found to be improved. CONCLUSIONS： Xinmaitong tablets have certain preventive and therapeutic effect on the model rats with AS by a mechanism which may be related to the reduction in lipid deposition and the size of an atherosclerotic plaque， the improvement in NO/ET balance and the alleviation of an endothelial injury. |
| 期刊： | 2016年第27卷第25期 |
| 作者： | 曹杰，王巧黎，赵宏，王珍 |
| AUTHORS： | CAO Jie，WANG Qiaoli，ZHAO Hong，WANG Zhen |
| 关键字： | 心脉通片；动脉粥样硬化；大鼠；内皮损伤；机制 |
| KEYWORDS： | Xinmaitong tablets； Atherosclerosis； Rats； Endothelial injury； Mechanism |
| 阅读数： | 229 次 |
| 本月下载数： | 2 次 |
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